MSCs For Treatment of Azoospermic Patients

Using of Bone Marrow Derived Mesenchymal Stem Cells For Treatment of Azoospermic Patients

In this study, we performed autologous BMDMSC transplantation to the testis of Azoospermic patients in a trial to enhance and activate the spermatogonial stem cells of the testis and aiming to produce motile sperm.

Bone marrow aspirated and stem cells were isolated, cultured and characterized using flow cytometer. Stem cells prepared according to GMP regulations then injected into rete testis using special syringe. Patients follow up will carried out for a year , three month interval. FSH, testosterone, testicular size as well as sexual potency will assessed every three months.

Inclusion Criteria:

• All Non obstructive Azoospermic Patients.
• Azoospermic Patients due to Administration of Chemo/Radiotherapy.

Exclusion Criteria:

• Patients with Testicular Cancer.
• Patients with Complete Deletion of Chromosome Y AZF (a,b,c) Regions.