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Local injection of 5-fluorouracil into a chalazion (stye) is as effective as local injection of triamcinolone (steroid) and incision and curettage for treatment of chalazia.
This is a prospective randomized interventional study comparing four current standard-of-care treatments for chalazia: incision and curettage, local injection of triamcinolone, local injection of 5-FU, and local injection of combination triamcinolone/5-FU.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Incision and Curettage | Active Comparator | A vertical incision over the area of chalazion will be done. Inflammatory material will be removed and the chalazion capsule will be excised. |
|
| Injection of Triamcinolone Acetonide | Active Comparator | 0.1 ml of triamcinolone is injected directly in the chalazion. |
|
| Injection of 5-fluorouracil | Active Comparator | 0.1 ml of 5-fluorouracil is injected directly in the lesion transconjunctivally. |
|
| Injection of triamcinolone/5FU mixture | Active Comparator | 0.1 ml of a 4:1 mixture of 4 parts 5-FU and 1 part triamcinolone is injected in the lesion. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 5-fluorouracil Injection | Drug | If the chalazion is present at follow-up visit, another injection of 5-FU will be given. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Size of chalazion | 4 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Simona Vuletic | Contact | 206-520-9728 | simona@uw.edu | |
| Ian Luttrell | Contact | 206-520-8305 | lutri@uw.edu |
| Name | Affiliation | Role |
|---|---|---|
| Matthew M Zhang, MD | University of Washington Eye Institute | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Washington Eye Institute at Harborview | Recruiting | Seattle | Washington | 98104 | United States |
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| ID | Term |
|---|---|
| D017043 | Chalazion |
| D010146 | Pain |
| ID | Term |
|---|---|
| D003560 | Cysts |
| D009369 | Neoplasms |
| D005141 | Eyelid Diseases |
| D005128 | Eye Diseases |
| D009461 |
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| ID | Term |
|---|---|
| D005472 | Fluorouracil |
| D014222 | Triamcinolone Acetonide |
| D014221 | Triamcinolone |
| D003475 | Curettage |
| ID | Term |
|---|---|
| D014498 | Uracil |
| D011744 | Pyrimidinones |
| D011743 | Pyrimidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
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| Triamcinolone Acetonide | Drug | If chalazion present at follow-up, another Triamcinolone injection will be done. |
|
|
| Incision and Curettage | Procedure | If chalazion present at follow-up visit, patient will be randomized to receive local injection of either triamcinolone, 5-FU, or triamcinolone/5-FU mixture. |
|
| Triamcinolone Acetonide/5-fluorouracil mixture | Drug | If chalazion persists at follow-up visit, another injection of triamcinolone/5-FU mixture will be done. |
|
| Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006571 |
| Heterocyclic Compounds |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |
| D013514 | Surgical Procedures, Operative |