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Healthy subjects take single dose of 80mg atorvastatin, then measured their circulating endothelial microparticles and flow-mediated vasodilation in the brachial artery by ultrasound at different time points.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| atorvastatin | Experimental | atorvastatin 20mg tablet, single dose of 80mg by mouth |
|
| placebo | Placebo Comparator | placebo 20mg tablet, single dose of 80mg by mouth |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| atorvastatin | Drug |
|
| |
| placebo |
| Measure | Description | Time Frame |
|---|---|---|
| change of circulating endothelial microparticles | from 1h to 24h after taking atorvastatin |
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Inclusion Criteria:
Exclusion Criteria:
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| ID | Term |
|---|---|
| D000069059 | Atorvastatin |
| D000073893 | Sugars |
| D013607 | Tablets |
| ID | Term |
|---|---|
| D011758 | Pyrroles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Drug |
|
|
| D006538 |
| Heptanoic Acids |
| D005227 | Fatty Acids |
| D008055 | Lipids |
| D002241 | Carbohydrates |
| D004304 | Dosage Forms |
| D004364 | Pharmaceutical Preparations |