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Malnutrition is a frequent complication in patients with liver cirrhosis. Most patients have decreased dietary intake due to ascites, hepatic encephalopathy and pro-inflammatory cytokines.
We hypothesized that branched chain aminoacids can improve nutritional status and delay episodes of hepatic encephalopathy
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Diet plus branched chain aminoacids | Experimental | High-fiber high-protein diet Oral supplement : branched chain aminoacids |
|
| Diet | Active Comparator | High-fiber high-protein diet |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Branched-chain aminoacids | Dietary Supplement |
| ||
| High-fiber high protein diet |
| Measure | Description | Time Frame |
|---|---|---|
| Nutritional status | Assessed by bioelectrical impedance vector analysis and mid-arm muscle circumference | At time of recruitment |
| Measure | Description | Time Frame |
|---|---|---|
| Hepatic Encephalopathy | At time of recruitment |
| Measure | Description | Time Frame |
|---|---|---|
| Nutritional status | Assessed by bioelectrical impedance vector analysis and mid-arm muscle circumference | 3 months follow-up |
| Nutritional status | Assessed by bioelectrical impedance vector analysis and mid-arm muscle circumference |
Inclusion Criteria:
Ambulatory patients Patients with confirmed diagnose of liver cirrhosis Patients classified as Child-Pugh A or Child Pugh B
Exclusion Criteria:
Acute or chronic renal failure Pregnancy Overt hepatic encephalopathy
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán" | Mexico City | 14000 | Mexico |
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| ID | Term |
|---|---|
| D008103 | Liver Cirrhosis |
| D006501 | Hepatic Encephalopathy |
| ID | Term |
|---|---|
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |
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| Other |
|
| 6 months follow-up |
| Hepatic encephalopathy | 6 months follow-up |
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D017093 | Liver Failure |
| D048550 | Hepatic Insufficiency |
| D001928 | Brain Diseases, Metabolic |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |