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| Name | Class |
|---|---|
| The Swedish Research Council | OTHER_GOV |
| Swedish Heart Lung Foundation | OTHER |
The purpose of this study is to determine the effects of sodium nitrate on resting metabolic rate, glucose uptake and formation of reactive oxygen species in humans.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sodium nitrate | Active Comparator | 0.1 mmol NaNO3 / kg bodyweight / day for three days. |
|
| Sodium Chloride | Placebo Comparator | 0.1 mmol NaCl / kg bodyweight / day for three days. |
|
| Sodium nitrite infusion | Active Comparator | Sodium nitrite (NaNO2) at a rate of 1, 10 and 100 nmol kg-1 min-1 (10 minutes per dose) was infused intravenously. |
|
| Saline infusion | Placebo Comparator | Saline at a rate corresponding to 1, 10 and 100 nmol NaCl kg-1 min-1 (10 minutes per dose) was infused intravenously. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Glucose Uptake | Other | Glucose uptake is measured by oral glucose tolerance test and euglycemic clamp |
|
| Measure | Description | Time Frame |
|---|---|---|
| Resting metabolic rate | Resting metabolic rate, measured after overnight fast using indirect calorimetry | day 4 |
| Measure | Description | Time Frame |
|---|---|---|
| Thyroid hormone status | day 4 | |
| Glucose uptake | Glucose uptake measured with oral glucose tolerance test and euglycemic clamp | day 4 |
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Inclusion Criteria:
Healthy volunteers
Exclusion Criteria Chronic medication Vegetarian Nicotine Users Known metabolic disease
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Karolinska Institutet | Stockholm | 17177 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21284982 | Background | Larsen FJ, Schiffer TA, Borniquel S, Sahlin K, Ekblom B, Lundberg JO, Weitzberg E. Dietary inorganic nitrate improves mitochondrial efficiency in humans. Cell Metab. 2011 Feb 2;13(2):149-59. doi: 10.1016/j.cmet.2011.01.004. |
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| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D001481 | Basal Metabolism |
| ID | Term |
|---|---|
| D004734 | Energy Metabolism |
| D008660 | Metabolism |
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| Resting metabolic rate | Other | Resting metabolic rate is measured by indirect calorimetry after an over-night fast |
|
| Nitrite infusion | Other | Sodium nitrite or saline was infused at escalating doses at a rate of 1, 10 or 100 nmol kg-1 min-1 (10 minutes per dose) in a randomized, double blinded cross-over fashion |
|
| Nitrite infusion |
Effect on resting metabolic rate when infusing escalating intravenous doses of sodium nitrite or saline solution |
| 30 minutes |