Predictive Factors of Obesity-hypoventilation Syndrome (OHS) Among Obese Subjects- ETUDE COHYPOB -

Predictive Factors of Obesity-hypoventilation Syndrome (OHS) Among Obese Subjects- ETUDE COHYPOB -

Investigate whether the course of an isolated nocturnal alveolar hypoventilation can predict the future occurrence of obesity-hypoventilation syndrome (OHS) in obese subjects

Inclusion criteria:

• Obese volunteer Subject (BMI> 30 kg/m2)
• Adults of either sex
• Social security affiliation
• Written informed consent

Exclusion criteria:

• Confirmed OHS at baseline defined by a daytime hypercapnia with PaCO2> 45mmHg
• Any cause of chronic respiratory failure other than obesity such as COPD, chest deformation, phrenic nerve paralysis, pulmonary fibrosis, neuromuscular disease, a history of mutilating thoracic surgery ...
• Obstructive ventilatory defect with FEV1/ FVC <70% post-bronchodilator
• Long term oxygen therapy, noninvasive ventilation, continuous positive airway pressure
• Any serious illness involving life-threatening within 3 years after inclusion
• Drug or alcohol abuse
• Pregnancy