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The purpose of this research study is to investigate the effectiveness of a technique designed to improve processing speed (i.e. the amount of time it takes to process information) in a Traumatic Brain Injury (TBI) population. The study is designed to study how well this technique can help people with TBI increase their processing speed and their ability to function better in everyday life.
The current proposal is designed to apply this treatment protocol to a large sample of individuals with moderate to severe TBI with documented impairment in PS. The goals of the trial are to (a) test the efficacy of this treatment protocol within a TBI population, (b) evaluate the impact of the treatment on everyday functioning, (c) evaluate the longer-term efficacy of the treatment, and (d) examine the utility of booster sessions in facilitating longer-term treatment effects. Individuals with moderate to severe TBI, with documented impairment in PS, will be randomly assigned to a treatment group or a control group. Both groups will undergo baseline, immediate post-treatment and long-term follow-up assessment consisting of: (1) a standardized neuropsychological battery and (2) an assessment of global functioning examining the impact of the treatment on daily activities. This design will allow us to assess the efficacy of SPT in persons with TBI and evaluate its impact on everyday life.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Treatment Group | Experimental | Computerized exercised will be administered on a laptop computer twice a week for 5 weeks (10 training sessions). |
|
| Placebo control group | Placebo Comparator | Computerized exercises will be administered on a laptop computer twice a week for 5 weeks (10 training sessions). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Speed of Processing Training | Behavioral |
| ||
| Placebo Control |
| Measure | Description | Time Frame |
|---|---|---|
| Symbol-Digit Modalities Test | Change in scores on standardized neuropsychological tests of Processing Speed using Symbol-Digit Modalities Test | Baseline (week 1), immediately post-intervention (week 7) and 3 months post-intervention |
| Measure | Description | Time Frame |
|---|---|---|
| TBI Quality of Life, Depression scale | Change in scores on self-report of emotional functioning, measured via questionnaire. The TBI QOL Depression scale measures depression. The range is 1-40. A higher score indicates greater depression. | Baseline (week 1), immediately post-intervention (week 7) and 3 months post-intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kessler Foundation | East Hanover | New Jersey | 07936 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40615123 | Derived | Goverover Y, Costa SL, DeLuca J, Chiaravalloti N. Does speed of processing training improve everyday life functional activity in traumatic brain injury: A pilot randomized controlled trial. Neuropsychol Rehabil. 2026 May;36(4):714-729. doi: 10.1080/09602011.2025.2526663. Epub 2025 Jul 4. |
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| ID | Term |
|---|---|
| D000070642 | Brain Injuries, Traumatic |
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D001930 | Brain Injuries |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| Behavioral |
|
| Perceived Deficits Questionnaire |
Change in scores on self-report of perceived cognitive deficits in daily life, measured via questionnaire. A higher score indicates greater perceived deficits in daily life. Range of scores on the scale is 0-80. |
| Baseline (week 1), immediately post-intervention (week 7) and 3 months post-intervention |
| TBI Quality of Life, Total Score | Change in scores on self-report of quality of life, measured via questionnaire. DV is the TBI-QOL total score. The range is 1-40. A higher score indicates better quality of life. | Baseline (week 1), immediately post-intervention (week 7) and 3 months post-intervention |
| D006259 |
| Craniocerebral Trauma |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |