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Logistics and financial
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Retrospective evaluation on the effect of splenic irradiation on clinical and hematological response and toxicity in patients with chronic lymphatic leukaemia (CLL).
The study will include patients with CLL treated with splenic irradiation in Maastro Clinic, Maastricht, The Netherlands, Maxima Medisch Centrum Veldhoven/Catharina hospital, Eindhoven, The Netherlands and Modena hospital, Modena, Italy. Data will be collected from patient records in an uniform database. Data will include demographic data, CLL stadium (RAI and Binet) at diagnosis and at the time of irradiation treatment, clinical data at diagnosis (haematology), splenic irradiation data, follow-up data such as date of progression or death
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with Chronic Lymphatic Leukemia | Patients with Chronic Lymphatic Leukemia treated with splenic irradiation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| splenic irradiation | Radiation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Clinical and haematological response | Clinical and haematological response measured by number of leucocytes and thrombocytes during and after irradiation. Hemoglobin and size of spleen during and after irradiation in the time period 2000 tot 2013 | 13 years |
| Measure | Description | Time Frame |
|---|---|---|
| Progression of chronic Lymphatic leukaemia | Progression of chronic Lymphatic leukaemia after irradiation in the time period 2000 tot 2013 | 13 years |
| Death | Patients will be followed from the time of splenic irradiation to death in the time period of 2000 tot 2013 |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with chronic lymphatic leukaemia (CLL).
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| Name | Affiliation | Role |
|---|---|---|
| Jacques Borger, dr. | Maastro Clinic, The Netherlands | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Maastro Clinic | Maastricht | Netherlands |
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| ID | Term |
|---|---|
| D015451 | Leukemia, Lymphocytic, Chronic, B-Cell |
| ID | Term |
|---|---|
| D015448 | Leukemia, B-Cell |
| D007945 | Leukemia, Lymphoid |
| D007938 | Leukemia |
| D009370 | Neoplasms by Histologic Type |
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| 13 years |
| Toxicity of splenic irradiation | Toxicity of splenic irradiation during and after irradiation measured by evaluating clinical toxicity based on the CTCAE version 3.0 during and after irradiation (2000 to 2013) | 13 years |
| D009369 |
| Neoplasms |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |