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| Name | Class |
|---|---|
| South-Eastern Norway Regional Health Authority | OTHER |
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This study will evaluate the association between n-3 polyunsaturated fatty acids and patient and graft survival. The association between other fatty acids and mortality and graft loss endpoints will also be evaluated.
This observational study focuses on the effects of marine n-3 polyunsaturated fatty acids (PUFAs) intake, measured as fatty acid levels in plasma phospholipids, and mortality and graft loss endpoints in renal transplant recipients. Data on morbidity, mortality and graft loss in The Norwegian Renal Registry is matched against data on fatty acid composition in a large renal transplantation cohort of approximately 2000 patients with a median follow up time of about 5 years. It is a follow up study, although retrospectively evaluated. It will evaluate the role of marine n-3 PUFAs as a prognostic marker in renal transplantation by investigating the association between the levels (weight percentage of total fatty acids) of marine n-3 PUFAs in plasma phospholipids and events, including mortality and graft loss.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Renal transplant recipients | No intervention. Measurements of plasma marine n-3 polyunsaturated fatty acids levels, indicating intake of fish and seafood. |
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| Measure | Description | Time Frame |
|---|---|---|
| All-cause mortality | First patient recruited October 1999 and all remaining patients were censored at August 2012. | Up to 12 years. |
| Measure | Description | Time Frame |
|---|---|---|
| Loss of function in the renal transplant. | As for primary endpoint. | Up to 12 years. |
| Measure | Description | Time Frame |
|---|---|---|
| Cause specific mortality rates. | As for the primary endpoint. Mortality rates for cardiac, cerebrovascular, infectious disease and malignancies. | Up to 12 years. |
| Cause specific graft loss. | As for the primary endpoints. Graft loss rates for rejection and recurrence as well as total and death censored graft loss will be registered. |
Inclusion Criteria:
Exclusion Criteria:
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Renal transplant recipients
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| Name | Affiliation | Role |
|---|---|---|
| Ivar Eide, MD | Oslo University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Oslo University Hospital, Rikshospitalet | Oslo | Oslo | 0027 | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26063768 | Derived | Eide IA, Jenssen T, Hartmann A, Diep LM, Dahle DO, Reisaeter AV, Bjerve KS, Christensen JH, Schmidt EB, Svensson M. The association between marine n-3 polyunsaturated fatty acid levels and survival after renal transplantation. Clin J Am Soc Nephrol. 2015 Jul 7;10(7):1246-56. doi: 10.2215/CJN.11931214. Epub 2015 Jun 10. |
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| ID | Term |
|---|---|
| D012059 | Rejection, Psychology |
| ID | Term |
|---|---|
| D012919 | Social Behavior |
| D001519 | Behavior |
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Plasma phospholipids.
| Up to 12 years. |
| Rejection rate. | As for the primary endpoint. | Up to 12 years. |