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Fatigue is one of the most common symptoms in individuals with Parkinson's Disease (PD). Past researches indicated that more than half of the individuals with PD demonstrated fatigue symptom. The severity of fatigue was also correlated to the quality of life in individuals with PD. Finding the contributions of the central and the peripheral factors to fatigue, building reliable fatigue indexes, and developing an effective training program for individuals with PD are very important.
The purpose of this project is to develop non-invasive method to monitor central and peripheral fatigue, to establish Virtual Reality(VR) anti-fatigue ergo cycling training paradigm, and to evaluate the long term training effect in individuals with PD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stage 1: Health group | No Intervention | To establish non-invasive fatigue monitoring method via testing healthy individuals. | |
| Stage 2: PD group | Experimental | To find the optimal feedback variables for anti-fatigue training on individuals with PD. |
|
| Stage 2: Health group | Experimental | Stage 2 controlled group |
|
| Stage 3: PD group | Experimental | To evaluate the effect of four weeks of VR anti-fatigue ergo cycling training on various fatigue components and functional abilities in individuals with PD. |
|
| Stage 3: PD controlled group | No Intervention | Stage 3 controlled group |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Virtual Reality anti-fatigue ergo cycling training (Self-made) | Procedure | To establish a Virtual Reality systems to reduce fatigue of cycling training for PD subjects. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Muscle twitch force | Measure of changes in muscle twitch force by interpolation twitch technique. | baseline, 1 week |
| Muscle voluntary activity level | Measure of changes in muscle voluntary activity level by interpolation twitch technique. | Baseline,1 week |
| Heart rate/Heart rate variability | Measure of changes in Heart rate/Heart rate variability. | Baseline,1 week |
| Borg's rate of perceived exertion | Measure of changes in Borg's rate of perceived exertion. | Baseline,1 week |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chang Gung University | Taoyuan | 333 | Taiwan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38588457 | Derived | Ernst M, Folkerts AK, Gollan R, Lieker E, Caro-Valenzuela J, Adams A, Cryns N, Monsef I, Dresen A, Roheger M, Eggers C, Skoetz N, Kalbe E. Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2024 Apr 8;4(4):CD013856. doi: 10.1002/14651858.CD013856.pub3. | |
| 36602886 |
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| Ernst M, Folkerts AK, Gollan R, Lieker E, Caro-Valenzuela J, Adams A, Cryns N, Monsef I, Dresen A, Roheger M, Eggers C, Skoetz N, Kalbe E. Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2023 Jan 5;1(1):CD013856. doi: 10.1002/14651858.CD013856.pub2. |
| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| D005221 | Fatigue |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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