The purpose of the current work is to determine the efficacy of the re-application of surgical prep solution in decreasing surgical site bacterial contamination following lower extremity surgery. Decreasing the extent of bacterial colonization of the skin surrounding the surgical site during the initial healing phases would theoretically decrease the rate of infection in high-risk persons.

Inclusion Criteria:

• Male and female
• Adults (18+)
• Both elective and non-elective procedures
• Lower extremity surgery performed below the knee and requiring post-operative splint immobilization for 2-3 weeks
• Able to understand and read the English language
• Signed informed consent

Exclusion Criteria:

• Pregnant (to be assessed the day of surgery per standard of care surgical protocol)
• Known allergies to chlorhexidine gluconate or isopropyl alcohol
• Multiple planned lower extremity surgeries
• Local skin disease
• Pre-existing or known infection at surgical site
• Open wounds or local abrasions
• Unable to or unwilling to follow through with study requirements