Incidence and Spectrum of Acute Kidney Injury in Cirrhotics and Assessment of New Biomarkers as Early Predictors of Acute Kidney Injury

500 patients with normal renal function will be prospectively studied and incidence, spectrum and natural history of AKI (Acute Kidney Injury) will be observed in them and in 200 patients with abnormal renal function fulfilling AKI (Acute Kidney Injury) criteria will be prospectively studied for 1 year. Also biomarkers will be studied and validated as early predictors of AKI (Acute Kidney Injury).

Inclusion Criteria:

- Group A: 500 patients of cirrhosis with normal baseline renal function will be enrolled Group B : 200 patients who present with AKI (Acute Kidney Injury) will be enrolled

Exclusion Criteria:

• Age < 18 or > 70 years
• Preexisting Chronic Renal Disease
• Patients with obstructive uropathy.
• Cirrhosis with HCC (HepatoCellular Carcinoma).
• Advanced cardiopulmonary disease
• Pregnancy
• Patients with extrahepatic malignancy