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| Name | Class |
|---|---|
| King's College Hospital NHS Trust | OTHER |
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Studies suggest that dietary omega-3 fatty acids influence the extent to which the time interval between each heart beat varies (heart rate variability; HRV). Low HRV is associated with increased risk of sudden cardiac death (SCD). The purpose of this research is to investigate the relationship between 24 hour parameters of HRV and blood omega-3 fatty acid levels in patients who have recently commenced haemodialysis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Chronic kidney disease, stage 5 | Patients with stage 5 chronic kidney disease who have recently commenced haemodialysis treatment (within 6-10 weeks of starting treatment) |
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| Measure | Description | Time Frame |
|---|---|---|
| Erythrocyte eicsapentaenoic acid (EPA) + docosahexaenoic acid (DHA) content (% weight of total fatty acids) | Primary independent variable | 6-10 wk after commencing haemodialysis treatment |
| 24 hour heart rate variability (Triangular index and SDNN) | Primary dependent variables. Triangular index and SDNN are indicators of overall variability | 6-10 weeks after commencing haemodialysis treatment |
| Measure | Description | Time Frame |
|---|---|---|
| 24 h heart rate variability - longer phase parameters | Parameters of longer phase HRV: LF, VLF and SDANN | 6-10 weeks after commencing haemodialysis |
| 24 h heart rate variability - short-phase parameters |
| Measure | Description | Time Frame |
|---|---|---|
| Complications of haemodialysis in first 6 weeks of starting treatment | Incidence of problems with dialysis access, inadequate urea reduction ratio, amount of excess oedematous fluid removed, serious adverse events | 0-6 weeks after commencing haemodialysis |
| Background dietary intakes |
Inclusion Criteria:
Exclusion Criteria:
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Patients attending King's College Hospital and Guy's and St Thomas' Hospitals who have recently commenced haemodialysis treatment.
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| Name | Affiliation | Role |
|---|---|---|
| Wendy Hall, PhD | King's College London | Principal Investigator |
| Iain Macdougall, FRCP | King's College Hospital NHS Trust | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| King's College London | London | SE1 9NH | United Kingdom | |||
| King's College Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Result | Pinto, A., MacLaughlin, H., Gray, R., & Hall, W. (2020). Heart rate variability and long chain n-3 PUFA in patients with chronic kidney disease commencing haemodialysis: A cross-sectional study. Proceedings of the Nutrition Society, 79(OCE2), E643. doi:10.1017/S0029665120005923 |
| Label | URL |
|---|---|
| Abstract (13th European Nutrition Conference, FENS 2019, 15-18 October 2019, Malnutrition in an Obese World: European Perspectives) | View source |
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| ID | Term |
|---|---|
| D051436 | Renal Insufficiency, Chronic |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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Blood Plasma Washed and isolated red blood cells
RMSSD, pNN50, HF
| 6-10 weeks after commencing haemodialysis |
| Nocturnal heart rate variability - all parameters | SDNN, Triangular index, LF, HF, VLF, SDANN, RMSSD, pNN50 calculating during nocturnal sleep-time | 6-10 weeks after commencing haemodialysis |
| Plasma EPA+DHA content (% weight of total fatty acids) | 6-10 weeks after commencing haemodialysis6-10 weeks after commencing haemodialysis |
Food frequency questionnaire |
| 6-10 weeks after commencing haemodialysis |
| History of sleep apnoea | Epworth Sleepiness scale and Berlin questionnaire, plus relevant medical history | 6-10 weeks after commencing haemodialysis |
| Weight | 6-10 weeks after commencing haemodialysis |
| Waist circumference | 6-10 weeks after commencing haemodialysis |
| 12 month average blood pressure | 12 months prior to commencing haemodialysis treatment |
| Plasma lipids | 6-10 weeks after commencing haemodialysis |
| C-reactive protein | 6-10 weeks after commencing haemodialysis |
| Serum electrolytes | Sodium, potassium, calcium, phosphate | 6-10 weeks after commencing haemodialysis |
| London |
| SE5 9RS |
| United Kingdom |
| Guy's and St Thomas' Hospital | London | United Kingdom |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |