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Infants showing high local pulmonary inflammation diagnosted by respiratory distress syndrome usually need the second or more pulmonary surfactant and is easier to developing to Brochopulmonary. Cursurf is used worldwide in infants with respiratory distress syndrome, Budesonide is a glucocorticoid with a high local anti-inflammatory effect.Our hypothesis is Cursurf combined with Budesonide could reduced the need of Cursurf and incidence of Brochopulmonary dysplasia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cursurf | No Intervention | The baby with respiratory distress syndrome was given Cursurf through intubation. | |
| Cursurf and Budesonide | Experimental | The baby with respiratory distress syndrome was given Cursurf and Budesonide through intubation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Budesonide | Drug | Experimental: Cursurf and Budesonide The baby with respiratory distress syndrome was given Cursurf and Budesonide through intubation |
|
| Measure | Description | Time Frame |
|---|---|---|
| need of pulmonary surfactant | The hypothesis is Cursurf/Budesonide could reduced the need of pulmonary surfactant | one month |
| Measure | Description | Time Frame |
|---|---|---|
| the incidence of bronchopulmonary dysplasia | the hypothesis is Cursurf and Budesonide could reduced the incidence of bronchopulmonary dysplasia. | gestional age 36 weeks or later |
| Measure | Description | Time Frame |
|---|---|---|
| need of intubation | The hypothesis is Cursurf/Budesonide could reduced the need of intubation | one month |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Pediatrics, Daping Hospital, Research Institute of Surgery, Third Military Medical University | Chongqing | Chongqing Municipality | 400042 | China |
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| ID | Term |
|---|---|
| D012128 | Respiratory Distress Syndrome |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D012120 | Respiration Disorders |
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| ID | Term |
|---|---|
| D019819 | Budesonide |
| ID | Term |
|---|---|
| D011282 | Pregnenediones |
| D011283 | Pregnenes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 |
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|
| Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |