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The purpose of this study is to compare postoperative immune function (e.g. NK cell activity) of fentanyl-based analgesic regimen versus local anesthetic wound infiltration-based anlagesic regimen after laparoscopic colorectal surgery
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| fentanyl-based analgesia | Experimental | fentanyl intravenous patient-controlled analgesia + additional pethidine |
|
| local anesthetic wound infiltration-based anlagesia | Experimental | continuous wound inflitration with ropivacaine + tramadol intravenous patient-controlled analgesia + additional ketorolac or propacetamol |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| fentanyl-based analgesia | Drug | fentanyl based patient-controlled analgesia + additional pethidine for postoperative 48 hour |
|
| Measure | Description | Time Frame |
|---|---|---|
| NK cell activity | NK cell activity : preoperation, POD 1, POD 2 | 48 hours |
| IL-2 | IL-2 level : preoperation, POD 1, POD 2 | 48 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Complication and recurrence | Postoperative complication, recurrence | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Inflammatory responses | White blood cell, neutrophil, C-reactive protein (CRP) : preoperation, POD 1, POD 2 | 48 hours |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Yonsei University College of Medicine | Sedoul | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40772525 | Derived | Nunez-Rodriguez E, Zhang H, Sah D, Cata JP. Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going? Adv Biol (Weinh). 2025 Oct;9(10):e00122. doi: 10.1002/adbi.202500122. Epub 2025 Aug 7. |
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| ID | Term |
|---|---|
| D000377 | Agnosia |
| ID | Term |
|---|---|
| D010468 | Perceptual Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| local anesthetic wound infiltration-based anlagesia | Drug | continuous wound inflitration with ropivacaine + tramadol patient-controlled analgesia + additional ketorolac or propacetamol for postoperative 48 hour |
|
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |