Exploring Biological Linkage Between Circadian Disruption and Cancer Progression

A Prospective Study of Exploring Possible Biological Linkage Between Circadian Disruption and Cancer Progression

The purpose of this study is to explore the possible association between the circadian disruption and cancer progression.

The biological markers that are assumed to bridge this association are measured and analyzed.

Inclusion Criteria:

• Age: 18-70
• Breast cancer patients who are getting chemotherapy for the first time in life
• Patients are either having stage 4 cancer or starting neoadjuvant chemotherapy.
• Patient have signed on the informed consent, and well understood the objective and procedure of this study

Exclusion Criteria:

• Patients already have received chemotherapy
• Patient had another cancer (except thyroid cancer) within 5 years
• Patient with severe medical condition
• Patient had taken psychiatric medication more than 1 month in life
• Patient worked the night shift for more than 1 month in 6 months