aggressive periodontitis is an inflammatory disease which damage the teeth supporting structures mostly in young patients. and has genetic basis.

a specific bacteria: Aggregatibacter actinomycetemcomitans (Aa) is associated with this disease, and found to damage leukocytes by using a specific leukotoxin.

in the research the investigators are aiming to find molecular and immunological basis to aggressive periodontitis.

Inclusion Criteria:

• patients in periodontal department
• healthy
• diagnosed with chronic/aggressive periodontal disease
• interested in participating the research

Exclusion Criteria:

• diagnosed with diabetes, heart disease, immunosuppression, thrombocytopenia, clotting enzyme deficiency.
• using alcohol, or drugs
• pregnancy