Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose of this study is to compare abdominal weight gain and fat distribution to changes in brain morphology in people taking antipsychotic medications.
Abdominal weight gain is a significant side effect of antipsychotic medications. It has even been suggested to be part of the pathology of severe mental illnesses. Studies have shown that in persons with bipolar disorder, increased body mass index (BMI) is associated with irregular changes in the brain. This association has not been tested in persons with psychosis. In this study, we will be measuring abdominal fat distribution as measured by MRI to see if this is associated with abnormal brain morphology.
Not provided
Not provided
Not provided
Not provided
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Abdominal distribution of visceral fat versus subcutaneous fat | Change over time in amounts of visceral and subcutaneous fat as measured by automated segmentation of a magnetic resonance image (MRI) | Baseline (within 2 weeks of admission), 12 weeks later, and prior to discharge |
| Changes in total brain volume | Change over time in total brain volume as measured by automated segmentation of a magnetic resonance image (MRI). | Baseline (within 2 weeks of admission), 12 weeks later, and prior to discharge |
| Changes in grey matter volume in the brain | Change over time in amounts of brain grey matter as measured by automated segmentation of a magnetic resonance image (MRI). | Baseline (within 2 weeks of admission), 12 weeks later, and prior to discharge |
| Changes in white matter volume in the brain | Change over time in amounts of brain white matter as measured by automated segmentation of a magnetic resonance image (MRI). | Baseline (within 2 weeks of admission), 12 weeks later, and prior to discharge |
| Changes in the volume of brain structures | Change over time in the volume of brain structures as measured by automated segmentation of a magnetic resonance image (MRI). | Baseline (within 2 weeks of admission), 12 weeks later, and prior to discharge |
| Measure | Description | Time Frame |
|---|---|---|
| Comparing changes in abdominal fat distribution/accumulation to psychosis symptom severity | To determine if an association exists between abdominal fat accumulation/distribution and psychosis symptom severity, as measured by the amounts of visceral and subcutaneous fat by automated segmentation of a magnetic resonance image (MRI) and standardized symptom rating scales, cognitive tests, and other neuropsychological examinations, respectively. |
Not provided
Inclusion Criteria:
Exclusion Criteria:
• None, other than those listed above
Not provided
Not provided
Not provided
Participants who have recently been seen at the BC (British Columbia) Psychosis Program at the University of British Columbia hospital.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Heidi N Boyda, Ph.D. | Contact | 604-875-2000 | 6484 | hnboyda@gmail.com |
| Delrae Fawcett, M.Sc. | Contact | 604-875-2000 | 6115 | delrae.fawcett@ubc.ca |
| Name | Affiliation | Role |
|---|---|---|
| Alasdair M Barr, Ph.D. | The University of British Columbia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| BC Mental Health & Addictions Research Institute | Recruiting | Vancouver | British Columbia | V5Z 4H4 | Canada |
Not provided
| ID | Term |
|---|---|
| D011618 | Psychotic Disorders |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
Not provided
Not provided
Not provided
Not provided
Not provided
| Baseline (within 2 weeks of admission), 12 weeks later, and prior to discharge |