Effect of Allopurinol Treatment on Insulin Resistance

Several studies showed that hyperuricemia is an independent risk factor for development of diabetes mellitus. However none of the previous studies have investigated the effect of lowering serum uric acid levels on insulin resistance of which is also named as prediabetes. With this background in mind, we aimed to test the effect of lowering serum uric acid level with allopurinol on insulin resistance.

Inclusion Criteria:

• Age ≥ 30
• Serum uric acid level ≥7mg/dL
• Glomerular filtration rate ≥60 ml/min

Exclusion Criteria:

• presence of Diabetes Mellitus
• history of gout
• history of allopurinol use
• body mass index ≥35 kg/m2
• proteinuria ≥ 1gr/ day
• presence of autoimmune disease
• rheumatology associated disease
• presence of hypothyroidism or hyperthyroidism
• presence of diseases which may cause chronic inflammation or microalbuminuria (e.g. malignancy, chronic liver disease, hypertension, chronic lung disease)