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To assess response to bronchodilation with tiotropium plus salbutamol in patients with severe emphysema and analyze relationships between bronchoreversibility response and semiquantitative computed-tomography based emphysema severity measures.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bronchodilators | Patients with severe heterogeneous emphysema selected as potential candidtes for lung volume reduction surgery. Bronchodilators employed for the study include albuterol 200µg and tiotropium bromide 18 µg administered by puffs following a first spirometry and plethysmography performed after a washout period of 48h from all bronchodilators and subsequently repeated within 30 min after bronchodilators administration. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bronchodilators | Drug | Administration of both albuterol and tiotropium bromide after a 48h period of washout from all bronchodilators, followed by spirometry and plethysmography |
|
| Measure | Description | Time Frame |
|---|---|---|
| post-bronchodilator FEV1 change | Assessed by spirometry carried out before and after administration of bronchodilators | 1 h |
| post-bronchodilator change in FVC | Assessed by spirometry carried out before and after administration of bronchodilators | 1h |
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Inclusion Criteria:
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Patients with severe heterogeneous emphysema selected as potential candidtes for lung volume reduction surgery
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| Name | Affiliation | Role |
|---|---|---|
| Eugenio Pompeo, MD | Tor Vergata University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fondazione Policlinico Tor Vergata | Recruiting | Rome | 00133 | Italy |
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| ID | Term |
|---|---|
| D004646 | Emphysema |
| D029424 | Pulmonary Disease, Chronic Obstructive |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
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| ID | Term |
|---|---|
| D001993 | Bronchodilator Agents |
| D000420 | Albuterol |
| D000069447 | Tiotropium Bromide |
| ID | Term |
|---|---|
| D001337 | Autonomic Agents |
| D018373 | Peripheral Nervous System Agents |
| D045505 | Physiological Effects of Drugs |
| D020228 | Pharmacologic Actions |
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|
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D020164 | Chemical Actions and Uses |
| D018927 | Anti-Asthmatic Agents |
| D019141 | Respiratory System Agents |
| D045506 | Therapeutic Uses |
| D004983 | Ethanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D000588 | Amines |
| D010627 | Phenethylamines |
| D005021 | Ethylamines |
| D012602 | Scopolamine Derivatives |
| D014326 | Tropanes |
| D053961 | Azabicyclo Compounds |
| D001372 | Aza Compounds |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D019086 | Bridged Bicyclo Compounds, Heterocyclic |
| D006572 | Heterocyclic Compounds, Bridged-Ring |