Bronchoreversibility and Radiologic Morphology of Emphysema

Response to Bronchodilation With Tiotropium Plus Salbutamol Correlates With Radiologic Morphology of the Lung in COPD of the Emphysematous Phenotype

To assess response to bronchodilation with tiotropium plus salbutamol in patients with severe emphysema and analyze relationships between bronchoreversibility response and semiquantitative computed-tomography based emphysema severity measures.

Inclusion Criteria:

• Radiologic evidence of severe heterogeneous emphysema
• GOLD COPD class III-IV
• No other significant pulmonary comorbidity
• Quit smoking since at least 4 months