Multiple-dose Pharmacokinetics of Ceftaroline During Continuous and Intermittent Renal Replacement Therapy in Patients Requiring Renal Replacement Therapy

Multiple-dose Pharmacokinetics of Ceftaroline During Continuous and Intermittent Renal Replacement Therapy in Patients Requiring Renal Replacement Therapy

The study will be conducted to investigate the pharmacokinetics of ceftaroline during continuous and intermittent renal replacement therapy.

Inclusion Criteria:

• Age >18 years, able to give written informed consent
• Suspected or proven bacterial infection requiring parenteral antibiotic therapy.
• Renal replacement therapy (continuous or intermittent)

Exclusion Criteria:

• Known hypersensitivity to ceftaroline or other cephalosporins, or severe hypersensitivity (anaphylactic reaction) to beta-lactam antibacterial agents.
• An expected survival of less than two days.
• Known pregnancy
• Coadministration of valproic acid or probenecid, which cannot be discontinued for the duration of the study
• Ceftaroline as monotherapy for resistent species or fungal infections.
• Other reasons oposing the study participation on the discretion of the investigators