Effectiveness of Subcutaneous Glargine On The Time To Closure of The Anion Gap in Patients Presenting to the Emergency Department With Diabetic Keto-acidosis

Effectiveness of Subcutaneous Glargine On The Time To Closure of The Anion Gap in Patients Presenting to the Emergency Department With Diabetic Keto-acidosis: A Pilot Study

To determine if co-administration of subcutaneous (SQ)Insulin glargine in combination with intravenous (IV) insulin decreases the time to resolution of ketoacidosis and requirement for ICU admission compared to IV insulin with delayed administration of SQ glargine for the treatment of diabetic ketoacidosis (DKA).

Inclusion Criteria:

• Age >18 years
• Blood Glucose >200
• potential of hydrogen (pH) < 7.3
• Bicarbonate < 18
• Ketonemia or Ketonuria
• Anion Gap > or = 16

Exclusion Criteria:

• Age < 18 years
• Pregnant
• End state renal disease (ESRD)
• Prisoners
• Patients in shock or requiring emergency surgery
• Those unwilling to consent for the trial
• Allergic to Insulin Glargine