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In France the prevalence of pre-lingual deafness is between 1 and 1.4 per 1000 habitants, and according to very conservative estimates, about 44 000 deaf persons use the sign language. Additionally, the prevalence of dementia in France is close to 1% (850 000 dements for a total population of 65 millions). The prevalence of dementia in pre-lingual deaf adults has also been described and is between 1 and 1.4 /100 000 habitants.
The Mini Mental State Examination (MMSE) of Folstein is a test recommended to perform the cognitive evaluation for the detection of mental disorders including dementia, and a consensual French version exists prepared by GRECO (Group of Research and Cognitive Assessments). However, to date, there are no simple, rapid and validated screening tests to study cognitive disorders in deaf persons who use the sign language. The only tests available allow a late diagnosis avoiding an optimal treatment of the patients.
The objective of this study is to assess the intrinsic quality of the tool MMS-LS, a mini-mental state examination that has been adapted to the sign language in order to monitor cognitive disorders in deaf people who speak sign language.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| deaf persons with potential dementia | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| application of the mini-mental state test | Behavioral |
|
| Measure | Description | Time Frame |
|---|---|---|
| Assessment of internal consistency of MMS-LS test for the diagnosis of cognitive impairment among deaf patients by a correlation analysis followed by Cronbach's alpha test | At baseline, 1 year and 2 years follow-up visits |
| Measure | Description | Time Frame |
|---|---|---|
| Description of MMS-LS test results | Explanatory Factors are: age, education level, characteristics of the sign language(fluency level, learning age, usage frequency, usage by other family members) | Baseline |
| Diagnostic performance and predictive values of MMS-LS test for acquired dementia. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Benoît Drion, MD | Groupement des Hôpitaux de l'Institut Catholique de Lille, Unité d'Accueil et de Soins des Sourds en Langue des Signes et Réseau Sourds et Santé | Study Director |
| Amélie Lansiaux, MD | Groupement des Hôpitaux de l'Institut Catholique de Lille, Medical Research Department | Study Chair |
| Isabelle Ridoux, MD | CHU de Rennes, Hôpital de Pontchaillou | Principal Investigator |
| Corine Gilda Scemama-Ammar, MD | Hôpital de la Conception, Pôle psychiatrie, Marseille | Principal Investigator |
| Charlotte Crinquette, MD | Groupement des Hôpitaux de l'Institut Catholique de Lille | Principal Investigator |
| Isabelle Bouillevaux, MD | CHRU de Nancy, Unité Régionale d'Accueil et de Soins pour Sourds et malentendants | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital de la Conception, Pôle psychiatrie Centre | Marseille | Bouches-du-Rhône | 13885 | France | ||
| Groupement des Hôpitaux de l'Institut Catholique de Lille |
| Type | Date | Date Unknown |
|---|---|---|
| Release | Mar 18, 2026 | |
| Reset | Apr 6, 2026 | |
| Release | Apr 14, 2026 | |
| Reset | May 1, 2026 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Mar 18, 2026 | Apr 6, 2026 | |||
| Apr 14, 2026 |
| ID | Term |
|---|---|
| D003638 | Deafness |
| D008569 | Memory Disorders |
| D012813 | Sign Language |
| ID | Term |
|---|---|
| D034381 | Hearing Loss |
| D006311 | Hearing Disorders |
| D004427 | Ear Diseases |
| D010038 | Otorhinolaryngologic Diseases |
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Sensitivity, specificity, positive and negative predictive values. |
| Baseline, 1 year and 2 years follow-up visits |
| Correlation between MMS-LS score and CDR level | We also check that patients having a suspicious CDR (0.5) have a superior MMS-LS score compared to patients having a CDR ≥ 1. | Baseline, 1 year and 2 years follow-up visits |
| Diagnostic performance and predictive values of MMS-LS test for suspected dementia. | Sensitivity, specificity, positive and negative predictive values | Baseline, 1 year and 2 years follow-up visits |
| Lille |
| Hauts-de-France |
| 59962 |
| France |
| CHU de Rennes, Hôpital de Pontchaillou | Rennes | Ille-et-Vilaine | 35000 | France |
| Unité Régionale d'Accueil et de Soins pour Sourds et malentendants - CHRU Nancy | Nancy | Meurthe-et-Moselle | 54000 | France |
| May 1, 2026 |
| D012678 |
| Sensation Disorders |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D019954 | Neurobehavioral Manifestations |
| D007802 | Language |
| D003142 | Communication |
| D001519 | Behavior |
| D008369 | Manual Communication |
| D009633 | Nonverbal Communication |