Safety and Efficacy Study of Enzalutamide in Patients With Nonmetastatic Castration-Resistant Prostate Cancer | NCT02003924 | Trialant

Safety and Efficacy Study of Enzalutamide in Patients With Nonmetastatic Castration-Resistant Prostate Cancer | NCT02003924 | Trialant

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: Male
Accepts Healthy Volunteers: No
Eligibility Criteria: Inclusion Criteria:

Histologically or cytologically confirmed adenocarcinoma of the prostate without neuroendocrine differentiation, signet cell, or small cell features;

Ongoing androgen deprivation therapy with a gonadotropin-releasing hormone (GnRH) agonist/antagonist or prior bilateral orchiectomy (medical or surgical castration);

Testosterone ≤ 50 ng/dL (≤ 1.73 nmol/L) at screening;

Progressive disease on androgen deprivation therapy at enrollment;

PSA and the screening PSA assessed by the central laboratory (central PSA) should be ≥ 2 µg/L (2 ng/mL:

PSA doubling time ≤ 10 months;

No prior or present evidence of metastatic disease;

Asymptomatic prostate cancer;

Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1;

Estimated life expectancy ≥ 12 months.

Exclusion Criteria:

Prior cytotoxic chemotherapy;

Use of hormonal therapy or biologic therapy for prostate cancer (other than approved bone targeting agents and GnRH agonist/antagonist therapy) or use of an investigational agent within 4 weeks of randomization;

Known or suspected brain metastasis or active leptomeningeal disease;

History of another invasive cancer within 3 years of randomization;

Absolute neutrophil count < 1000/μL, platelet count < 100,000/μL, or hemoglobin < 10 g/dL (6.2 mmol/L) at screening;

Total bilirubin ≥ 1.5 times the upper limit of normal;

Creatinine > 2 mg/dL (177 µmol/L) at screening;

Albumin < 3.0 g/dL (30 g/L) at screening;

History of seizure or any condition that may predispose to seizure;

Clinically significant cardiovascular disease;

Gastrointestinal disorder affecting absorption;

Major surgery within 4 weeks of randomization;

Hypersensitivity reaction to the active pharmaceutical ingredient or any of the capsule components, including Labrasol, butylated hydroxyanisole, and butylated hydroxytoluene;

Any concurrent disease, infection, or comorbid condition that interferes with the ability of the patient to participate in the trial, which places the patient at undue risk, or complicates the interpretation of data, in the opinion of the investigator or medical monitor.

Urological Associates of Southern Arizona, PC

Tucson, Arizona 85741, United States

Ronald Reagan UCLA Medical Center

Los Angeles, California 90095, United States

UCLA Clark Urology Center

Los Angeles, California 90095, United States

University of California, Irvine Medical Center

Orange, California 92868, United States

Urology Associates of San Luis Obispo, a Medical Group, Inc

San Luis Obispo, California 93405, United States

Urology Associates, P.C.

Englewood, Colorado 80113, United States

c/o Lynn Buchwalder

New Haven, Connecticut 06510, United States

C/O Thomas Ferencz, RPh, BCOP, Smilow Cancer Hospital at Yale-New Haven

New Haven, Connecticut 06510, United States

Smilow Cancer Center at Yale New Haven-Hospital

New Haven, Connecticut 06510, United States

Yale New Haven Hospital

New Haven, Connecticut 06510, United States

Yale University School of Medicine

New Haven, Connecticut 06520, United States

Lakeland Regional Cancer Center

Lakeland, Florida 33805, United States

Urology of Indiana, LLC

Carmel, Indiana 46032, United States

First Urology, PSC

Jeffersonville, Indiana 47130, United States

IU Health Arnett Cancer Care

Lafayette, Indiana 47904, United States

Kansas City Urology Care, PA

Overland Park, Kansas 66211, United States

GU Research Network/ Wichita Urology Group

Wichita, Kansas 67226, United States

Chesapeake Urology Research Associates

Baltimore, Maryland 21237, United States

University of Michigan Health System

Ann Arbor, Michigan 48109, United States

Michigan Institute of Urology

Troy, Michigan 48084, United States

GU Research Network

Omaha, Nebraska 68130, United States

Brooklyn Urology Research Group

Brooklyn, New York 11201, United States

Premier Medical Group of the Hudson Valley

Newburgh, New York 12550, United States

Duke University Medical Center

Cary, North Carolina 27518, United States

Carolina Urology Partners, PLLC

Charlotte, North Carolina 28277, United States

Carolina Urology Partners, PLLC

Gastonia, North Carolina 28054, United States

Gaston Medical Associates

Gastonia, North Carolina 28054, United States

Carolina Urology Partners, PLLC

Huntersville, North Carolina 28078, United States

Duke Women's Cancer Care Raleigh

Raleigh, North Carolina 27607, United States

Clinical Research Solutions

Middleburg Heights, Ohio 44130, United States

Oregon Urology Institute

Springfield, Oregon 97477, United States

Lancaster Urology

Lancaster, Pennsylvania 17604, United States

Carolina Urologic Research Center

Myrtle Beach, South Carolina 29572, United States

Vanderbilt University Medical Center, Dept. of Urologic Surgery

Nashville, Tennessee 37232, United States

Vanderbilt University Medical Center, The Urologic Clinic

Nashville, Tennessee 37232, United States

Urology San Antonio

San Antonio, Texas 78229, United States

Urology of Virginia, PLLC

Virginia Beach, Virginia 23462, United States

COIBA(Centro de Oncologia e Investigacion Buenos Aires)

Berazategui, Buenos Aires B1884BBF, Argentina

Centro Medico Austral(OMI)

CABA, Buenos Aires C1019ABS, Argentina

Centro de Urologia

CABA, Buenos Aires C1120AAT, Argentina

Hospital Italiano de Buenos Aires

CABA, Buenos Aires C1199BB, Argentina

Sanatorio Parque

Rosario, Santa Fe Province CP2000, Argentina

Instituto De Oncologia De Rosario

Rosario, Santa Fe Province S200KZE, Argentina

Clinica Universidad Reina Fabiola

Córdoba, X5004HFP, Argentina

Hospital Privado Centro Medico de Cordoba

Córdoba, X5016KEH, Argentina

Centro Oncologico Riojano Integral (CORI)

La Rioja, F5300C0E, Argentina

The Canberra Hospital

Garran, Australian Capital Territory 2605, Australia

Border Medical Oncology Research Unit

Albury, New South Wales 2640, Australia

The Border Cancer Hospital Dispensary

Albury, New South Wales 2640, Australia

The Border Cancer Hospital

Albury, New South Wales 2640, Australia

Sydney cancer centre

Concord, New South Wales 2139, Australia

Epic pharmacy

Lismore, New South Wales 2480, Australia

North Coast Cancer Institute

Lismore, New South Wales 2480, Australia

Macquarie University Hospital

North Ryde, New South Wales 2109, Australia

Macquarie University

North Ryde, New South Wales 2109, Australia

Epic Pharmacy Port Macquarie base hospital

Port Macquarie, New South Wales 2444, Australia

Mid North Coast Cancer Institute

Port Macquarie, New South Wales 2444, Australia

Royal North Shore Hospital

St Leonards, New South Wales 2065, Australia

The Tweed Hospital

Tweed Heads, New South Wales 2485, Australia

Australian Clinical Trials

Wahroonga, New South Wales 2076, Australia

Sydney Adventist Hospital

Wahroonga, New South Wales 2076, Australia

Calvary Mater Newcastle

Waratah, New South Wales 2298, Australia

Westmead Hospital

Westmead, New South Wales 2145, Australia

Icon Cancer Care Wesley

Auchenflower, Queensland 4066, Australia

River City Pharmacy - APHS

Auchenflower, Queensland 4066, Australia

Icon Cancer Care Chermside

Chermside, Queensland 4032, Australia

Icon Cancer Care South Brisbane

South Brisbane, Queensland 4101, Australia

Integrated Clinical Oncology Network (ICON)

South Brisbane, Queensland 4101, Australia

Icon Cancer Care Southport

Southport, Queensland 4215, Australia

Tasman Oncology Research Pty Ltd

Southport, Queensland 4215, Australia

Princess Alexandra Hospital

Woolloongabba, Queensland 4102, Australia

Adelaide Cancer Centre

Kurralta Park, South Australia 5037, Australia

Ashford Cancer Centre Research

Kurralta Park, South Australia 5037, Australia

Cancer Care SA Pty Ltd

Kurralta Park, South Australia 5037, Australia

Tenpharm Pty Ltd trading as EPIC Pharmacy Tennyson

Kurralta Park, South Australia 5037, Australia

Box Hill Hospital (Eastern health)

Box Hill, Victoria 3128, Australia

Eastern Clinical Research Unit (Eastern Health)

Box Hill, Victoria 3128, Australia

Cabrini Hospital Brighton

Brighton, Victoria 3186, Australia

Monash Medical Centre

Clayton, Victoria 3168, Australia

Austin Health, Austin Hospital

Heidelberg, Victoria 3084, Australia

Cabrini Hospital Malvern

Malvern, Victoria 3144, Australia

Cabrini Hospital- Education and Research Precinct

Malvern, Victoria 3144, Australia

Peter MacCallum Cancer Centre

Melbourne, Victoria 3000, Australia

Sunshine Hospital

St Albans, Victoria 3021, Australia

Krankenhaus Barmherzige Schwestern Linz, Abteilung Radiologie

Linz, Upper Austria 4010, Austria

Krankenhaus Barmherzige Schwestern Linz, Abteilung Urologie

Linz, Upper Austria 4010, Austria

St. Vincent's Hospital, PET - CT Center

Linz, Upper Austria 4010, Austria

Isotopix, Ambulatorium fuer Nuklearmedizin

Vienna, 1090, Austria

Medizinische Universitaet Wien, Universitaetsklinik fuer Innere Medizin I

Vienna, 1090, Austria

Diagnosezentrum Meidling GesmbH

Vienna, 1120, Austria

Algemeen Ziekenhuis Groeninge

Kortrijk, West-vlaanderen 8500, Belgium

Clinique Universitaire de Bruxelles Hopital Erasme

Brussels, 1070, Belgium

Vzw Algemeen Ziekenhuis Maria Middelares

Ghent, 9000, Belgium

Universitaire Ziekenhuizen Leuven

Leuven, 3000, Belgium

Centre Hospitalier Universitaire de Liege, Site du Sart-Tilman

Liège, 4000, Belgium

Hospital Sao Rafael

Salvador, Estado de Bahia 41253-190, Brazil

Liga Paranaense de Combate ao cancer / Hospital Erasto Gaertner

Curitiba, Paraná 81520-060, Brazil

Instituto D'Or de Pesquisa e Ensino (IDOR)

Rio de Janeiro, Rio de Janeiro 22.281-100, Brazil

Associacao Hospital de Caridade de Ijui

Ijuí, Rio Grande do Sul 98700-000, Brazil

Hospital de Clínicas de Passo Fundo

Passo Fundo, Rio Grande do Sul 99010-260, Brazil

Hospital de Clinicas de Porto Alegre

Porto Alegre, Rio Grande do Sul 90035-903, Brazil

CLINIONCO - Clinica de Oncologia de Porto Alegre Ltda.

Porto Alegre, Rio Grande do Sul 90430-090, Brazil

Hospital Sao Lucas da PUCRS

Porto Alegre, Rio Grande do Sul 90610-000, Brazil

Hospital das Clinicas da Faculdade de Ciencias Medicas da UNICAMP

Campinas, São Paulo 13083-970, Brazil

Hospital Amaral Carvalho - Fundacao Dr. Amaral Carvalho

Jaú, São Paulo 17210-080, Brazil

Fundacao Dr. Amaral Carvalho

Jaú, São Paulo 17210-120, Brazil

Fundacao Dr.Amaral Carvalho

Jaú, São Paulo 17210-120, Brazil

Centro de Estudos e Pesquisas em Hematologia e Oncologia (CEPHO)

Santo André, São Paulo 09060-650, Brazil

Hospital Israelita Albert Einstein

Sao Paulp, São Paulo 05652-900, Brazil

IAMSPE-Inst. de Assist. ao Servidor Publico Estadual

São Paulo, São Paulo 04039-901, Brazil

Hospital Universitario Pedro Ernesto - UERJ

Rio de Janeiro, 20551-030, Brazil

Oncologia Rede D'Or

Rio de Janeiro, 22271-110, Brazil

Tom Baker Cancer Centre

Calgary, Alberta T2N 4N2, Canada

Cross Cancer Institute

Edmonton, Alberta T6G 1Z2, Canada

Vancouver Prostate Centre

Vancouver, British Columbia V5Z 1M9, Canada

Manitoba Prostate Centre CancerCare Manitoba

Winnipeg, Manitoba R3E 0V9, Canada

NS Health Authority, Queen Elizabeth II Health Sciences Centre

Halifax, Nova Scotia B3H 2Y9, Canada

The Male/Female Health and Research Centre

Barrie, Ontario L4M 7G1, Canada

McMaster Institute of Urology @ St. Joseph's Healthcare Hamilton

Hamilton, Ontario L8N 4A6, Canada

Urology Associates / Urologic Medical Research

Kitchener, Ontario N2N 2B9, Canada

London Regional Cancer Program - Victoria Hospital, London Health Sciences Centre(LHSC)

London, Ontario N6A 4L6, Canada

Urology Reasearch - Victoria Hospital, London Health Sciences Centre(LHSC)

London, Ontario N6A 5W9, Canada

SunnyBrook Health Sciences Centre

Toronto, Ontario M4N 3M5, Canada

University Health Network- Princess Margaret Cancer Centre

Toronto, Ontario M5G2M9, Canada

Urology South Shore Research

Greenfield Park, Quebec J4V 2H3, Canada

Centre Hospitalier de l'Université de Montréal

Montreal, Quebec H2X 3E4, Canada

McGill University Health Centre

Montreal, Quebec H4A 3J1, Canada

CHU de Quebec

Québec, Quebec G1R 2J6, Canada

Fundacion Arturo Lopez Perez

Santiago, 7500836, Chile

Centro de Investigaciones Clinicas Vina del Mar

Santiago, 7630370, Chile

Instituto Clinico Oncologico del Sur (ICOS)

Temuco, 4810469, Chile

Instituto Oncologico Ltda.

Viña del Mar, 2540364, Chile

Centro de Investigaciones Clinicas

Viña del Mar, 2540488, Chile

Peking University First Hospital

Beijing, Beijing Municipality 100034, China

Beijing Cancer Hospital

Beijing, Beijing Municipality 100142, China

Peking University Third Hospital

Beijing, Beijing Municipality 100191, China

Beijing Hospital

Beijing, Beijing Municipality 100730, China

Peking Union Medical College Hospital

Beijing, Beijing Municipality 100730, China

Chongqing Cancer Hospital

Chongqing, Chongqing Municipality 400030, China

The First Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong 510120, China

Zhongnan Hospital of Wuhan University

Wuhan, Hubei 430030, China

Office of Hongqian Guo

Nanjing, Jiangsu 210008, China

Jiangsu Cancer Hospital

Nanjing, Jiangsu 210009, China

Jiangsu Province Hospital

Nanjing, Jiangsu 210029, China

The Second Affiliated Hospital of Soochow University

Suzhou, Jiangsu 215004, China

Wuxi People's Hospital

Wuxi, Jiangsu 214023, China

Qingdao Municipal Hospital (East Hospital)

Qingdao, Shandong 266071, China

Fudan University Shanghai Cancer Center

Shanghai, Shanghai Municipality 200032, China

Huashan Hospital Fudan University

Shanghai, Shanghai Municipality 200040, China

Shanghai First People's Hospital

Shanghai, Shanghai Municipality 200080, China

Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Shanghai, Shanghai Municipality 200092, China

Shanghai Changhai Hospital

Shanghai, Shanghai Municipality 200433, China

The First Affiliated Hospital of Xi'an Jiaotong University

Xi’an, Shanxi 710061, China

The Second Affiliated Hospital of Zhejiang University School of Medicine

Hangzhou, Zhejiang 310009, China

The First Affiliated Hosptial of Wenzhou Medical University

Wenzhou, Zhejiang 325000, China

UNIMED Medical Institute Limited

Hong Kong, China

The Second Hospital of Tianjin Medical University

Tianjin, 300211, China

Rigshospitalet 7521

Copenhagen, Norrebro 2200, Denmark

Copenhagen Prostate Cancer Center

Copenhagen, N 2200, Denmark

Aarhus University Hospital

Arhus N, 8200, Denmark

Rigshospitalet

Copenhagen, 2100, Denmark

Frederiksberg Hospital

Frederiksberg, 2000, Denmark

Herlev Hospital

Herlev, 2730, Denmark

Odense University Hospital

Odense C, 5000, Denmark

Vejle Sygehus

Vejle, 7100, Denmark

Docrates Syopasairaala

Helsinki, 00180, Finland

Helsingin yliopistollinen keskussairaala, Meilahden sairaala

Helsinki, 00290, Finland

Oulun yliopistollinen sairaala

Oulu, 90220, Finland

Satakunnan keskussairaala

Pori, 28500, Finland

Tampereen yliopistollinen Sairaala

Tampere, 33520, Finland

Hopitaux Universitaires de Strasbourg - Hopital Civil

Strasbourg, Alsace FR-67091, France

Centre Paul Strauss

Strasbourg, Bas-rhin 67000, France

Clinique Sainte Anne

Strasbourg, Bas-rhin 67000, France

Societe MIM, Clinique Sainte Anne

Strasbourg, Bas-rhin 67000, France

Institut Curie

Paris, Paris 75005, France

Centre Hospitalier Lyon Sud

Pierre-Bénite, Rhone 69495, France

Institut Gustave Roussy

Villejuif, VAL DE Marne 94805, France

Institut de Cancerologie de l'Ouest - Paul Papin

Angers, 49055, France

Institut Sainte Catherine

Avignon, 84918, France

Institut Bergonie

Bordeaux, 33076, France

Urologic Oncology Department- Institut Bergonie - Centre regional de Lutte contre le Cancer

Bordeaux, 33076, France

Cabinet de Radiologie

Brest, 29200, France

CHU Brest Hopital Morvan

Brest, 29200, France

Clinique pasteur Lancroze

Brest, 29200, France

Clinique Pasteur-Lanroze

Brest, 29200, France

CHRU de Brest

Brest, 29609, France

Hopital Pasteur

Colmar, 68024, France

Hopitaux Civils de Colmar

Colmar, 68024, France

Centre Regional de lutte Contre le Cancer Georges Francois Leclerc

Dijon, 21000, France

Clinique Victor Hugo

Le Mans, 72000, France

Hopital Calude Huriez - CHU Lille

Lille, 59037, France

Centre de Medecine Nucleaire LUMEN

Lyon, 69008, France

Centre Leon Berard

Lyon, 69008, France

Hopital Edouard Herriot - CHU Lyon

Lyon, 69437, France

Hopital Nord

Marseille, 13915 Cedex 20, France

ICM Val D'Aurelle

Montpellier, 34298, France

Hopital Europeen Georges Pompidou

Paris, 75908, France

Centre Hospitalier Lyon Sud

Pierre-Bénite, 69495, France

CHU Poitiers - Hopital la Miletrie

Poitiers, 86021, France

Institut de Cancerologie de I'Ouest - Rene Gauducheau

Saint-Herblain, 44805, France

Institut Claudius Regaud

Toulouse, 31059 Cedex 9, France

IUCT-Oncopole

Toulouse, 31059, France

Clinique Pasteur - CIMOF

Toulouse, 31076, France

Clinique Pasteur- Service Imagerie et Radiologie

Toulouse, 31076, France

Clinique Pasteur

Toulouse, 31076, France

Universitatsmedizin Mannheim, Medizinische Fakultat Mannheim der Universitat Heidelberg

Mannheim, Baden-Wurttemberg 68167, Germany

Studienpraxis Urologie

Nürtingen, Baden-Wurttemberg 72622, Germany

MVZ Zentrum fuer Diagnostische Radiologie und Nuklearmedizin Braunschweig GmbH

Braunschweig, Lower Saxony 38102, Germany

Staedtisches Klinikum Braunschweig

Braunschweig, Lower Saxony 38126, Germany

Hannover Medical School

Hanover, Lower Saxony 30625, Germany

Medizinische Hochschule Hannover

Hanover, Lower Saxony 30625, Germany

RWTH University Aachen

Aachen, North Rhine-Westphalia 52057, Germany

Uniklinik der RWTH Aachen

Aachen, North Rhine-Westphalia 52074, Germany

Clinic of Radiology

Aachen, North Rhine-Westphalia D-52074, Germany

Universitaetsklinikum Carl Gustav Carus an der TU Dresden

Dresden, Saxony 01307, Germany

Charite, Campus Benjamin Franklin

Berlin, 12200, Germany

Charite, Universitaetsmedizin Berlin

Berlin, 12200, Germany

Martini-Klinik am UKE GmbH

Hamburg, 20246, Germany

Diagnostikzentrum Esslingen

Kirchheim, 73230, Germany

University General Hospital of Heraklion, Urology Clinic

Heraklion, Crete 71110, Greece

General Hospital of Athens"Korgialeneio-Benakeio EES".Urology Clinic

Athens, 11526, Greece

General Hospital of Athens "Alexandra", Therapeutic Clinic

Athens, 11528, Greece

University General Hospital of Larissa, Urology Department

Larissa, 41110, Greece

University General Hospital of Patras, Oncology Department, Internal Medicine Clinic

Pátrai, 26504, Greece

General Hospital" Papageorgiou",B' Univ.Urology Clinic

Thessaloniki, 56429, Greece

Queen Mary Hospital

Hong Kong, Hong Kong

Tuen Mun Hospital

Hong Kong, Hong Kong

Prince of Wales Hospital

Shatin, Hong Kong

Laboratorio Medicina Nucleare-Ospedale G.B. Morgagni-Pierantoni

Forlì, FC 47121, Italy

Farmacia, Azienda Socio Sanitaria Territoriale di Cremona

Cremona, 26100, Italy

Medicina Nucleare, Azienda Socio Sanitaria Territoriale di Cremona

Cremona, 26100, Italy

Servizio di Radiologia, Azienda Socio Sanitaria Territoriale di Cremona

Cremona, 26100, Italy

Struttura Complessa di Oncologia, Azienda Socio Sanitaria Territoriale di Cremona

Cremona, 26100, Italy

U.O. di Oncologia, Ospedale Civile Degli Infermi

Faenza (RA), 48018, Italy

U.O. di Radiologia, Ospedale Civile degli Infermi

Faenza (RA), 48018, Italy

U.O. di Oncologia, Ospedale Civile Umberto I

Lugo (RA), 48022, Italy

U.O. di Radiologia, Ospedale Civile Umberto I

Lugo (RA), 48022, Italy

Laboratorio Farmaci Antiblastici

Meldola (FC), 47014, Italy

U.O. Oncologia Medica

Meldola (FC), 47014, Italy

UO Radiologia

Meldola (FC), 47014, Italy

Dipartimento di Radiologia, Ospedale San Raffaele

Milan, 20132, Italy

Servizio di Farmacia, Ospedale San Raffaele

Milan, 20132, Italy

U.O. di Medicina Nucleare e Centro PET, Ospedale San Raffaele

Milan, 20132, Italy

U.O. di Urologia, Ospedale San Raffaele

Milan, 20132, Italy

Farmacia Studi Clinici e Sperimentali, Fondazione IRCCS Istituto Nazionale dei Tumori

Milan, 20133, Italy

S.C. di Oncologia Medica 1, Fondazione IRCCS Istituto Nazionale dei Tumori

Milan, 20133, Italy

S.C. Diagnostica Radiologica 2, Fondazione IRCCS Istituto Nazionale dei Tumori

Milan, 20133, Italy

Divisione di Radiologia, Istituto Europeo di Oncologia

Milan, 20141, Italy

Reparto Oncologia Medica Urogenitale e Cervico Facciale, Istituto Europeo di Oncologia

Milan, 20141, Italy

Servizio Farmacia, Istituto Europeo di Oncologia

Milan, 20141, Italy

Farmacia Interna, Azienda Ospedaliero-Universitaria Policlinico di Modena

Modena, 41124, Italy

Medicina Nucleare, Azienda Ospedaliero-Universitaria Policlinico di Modena

Modena, 41124, Italy

Radiologia I, Azienda Ospedaliero-Universitaria Policlinico di Modena

Modena, 41124, Italy

U.O.S.C. di Oncologia Medica, A.O.R.N. "A. Cardarelli"

Naples, 80131, Italy

Farmacia Ospedaliera, AOU San Luigi Gonzaga

Orbassano (TO), 10043, Italy

SCDU Oncologia Medica II Pad, AOU San Luigi Gonzaga

Orbassano (TO), 10043, Italy

SCDU Radiodiagnostica, AOU San Luigi Gonzaga

Orbassano (TO), 10043, Italy

SS Medicina Nucleare, AOU San Luigi Gonzaga

Orbassano (TO), 10043, Italy

Farmacia, Istituto Oncologico Veneto (IOV)

Padova, 35128, Italy

IRCCS - Istituto Oncologico Veneto (IOV), UOC Oncologia Medica 1

Padova, 35128, Italy

Medicina Nucleare, Istituto Oncologico Veneto (IOV)

Padova, 35128, Italy

UOC Radiodiagnostica Oncologica, Istituto Oncologico Veneto (IOV)

Padova, 35128, Italy

Dipartimento di Onco-Ematologia Ospedale Santa Maria delle Croci

Ravenna, 48121, Italy

Servizio di Farmacia, AUSL di Ravenna

Ravenna, 48121, Italy

Servizio di Radiologia, AUSL di Ravenna

Ravenna, 48121, Italy

Azienda Ospedaliera S. Camillo Forlanini, UOC per il governo clinico in Oncologia Medica

Roma, 00152, Italy

U.O. di Oncologia Medica, Ospedale Santa Chiara

Trento, 38122, Italy

U.O. Farmacia, Ospedale Santa Chiara

Trento, 38122, Italy

U.O. Radiologia, Ospedale Santa Chiara

Trento, 38122, Italy

Universiti Kebangsaan Malaysia Medical Centre

Cheras, Kuala Lumpur 56000, Malaysia

Sarawak General Hospital

Kuching, Sarawak 93586, Malaysia

Subang Jaya Medical Centre Sdn. Bhd.

Subang Jaya, Selangor 47500, Malaysia

Hospital Kuala Lumpur

Kuala Lumpur, 50586, Malaysia

University Malaya Medical Centre

Kuala Lumpur, 59100, Malaysia

Maastricht University Medical Centre

Maastricht, AZ 5202, Netherlands

Catharina Ziekenhuis

Eindhoven, North Brabant 5623 EJ, Netherlands

Netherlands Cancer Institute

Amsterdam, 1066 CX, Netherlands

Albert Schweitzer Ziekenhuis

Dordrecht, 3318 AT, Netherlands

University Medical Center Groningen

Groningen, 9700 RB, Netherlands

Radboud University Nijmegen Medical Centre

Nijmegen, 6525 GA, Netherlands

Canterbury District Health Board

Christchurch, Canterbury 8140, New Zealand

Palmerston North Hospital

Palmerston North, Manawatu 4414, New Zealand

Waikato Urology Research LTD

Hamilton, Waikato Region 3204, New Zealand

Cancer and Blood Research

Auckland, 1023, New Zealand

Uniwersyteckie Centrum Kliniczne

Gdansk, 80-952, Poland

UROMEDYK, Poradnia Urologiczna

Kielce, 25-112, Poland

Malopolskie Centrum Medyczne s.c.

Krakow, 30-510, Poland

Wojewodzki Szpital Specjalistyczny im. Stefana Kardynala Wyszynskiego SPZOZ

Lublin, 20-718, Poland

Wojewodzki Szpital Specjalistyczny im. Janusza. Korczaka

Słupsk, 76-200, Poland

Profesorskie Centrum Medyczne Optimum

Wroclaw, 50-421, Poland

Centrum Medyczne Melita Medical

Wroclaw, 50-449, Poland

Wro Medica

Wroclaw, 51-685, Poland

Lexmedica

Wroclaw, 53-114, Poland

Federal State Budgetary Institution "N.N. Blokhin Russian Cancer Research Center"

Moscow, 115478, Russia

P. Hertsen Moscow Oncology Research Institute - branch of the National Medical Research

Moscow, 125284, Russia

State Budgetary Healthcare Institution City Multifield Hospital No.2

Saint Petersburg, 194354, Russia

SBEI HPE "First Pavlov State Medical University of St. Petersburg" of

Saint Petersburg, 197002, Russia

SBEI HPE "First Pavlov State Medical University of St. Petersburg" of

Saint Petersburg, 197022, Russia

Saint-Petersburg State Budgetary Healthcare Institution "Hospital for Veterans of War"

Saint Petersburg, 197183, Russia

SBHI "Saint-Petersburg clinical scientific

Saint Petersburg, 197758, Russia

SBEI of HPE "Bashkir State Medical University" of MoH of the RF

Ufa, 450073, Russia

Clinical Center Of Serbia, Clinic of Urology

Belgrade, 11000, Serbia

Clinical Center "Dr Dragisa Misovic -Dedinje", Clinic of Urology

Belgrade, 11040, Serbia

Clinical Center "Bezanijska Kosa", Department of Urology

Belgrade, 11080, Serbia

Clinical Center Zemun

Belgrade, 11080, Serbia

National University Hospital

Singapore, 119074, Singapore

National Cancer Centre Singapore

Singapore, 169610, Singapore

Fakultna nemocnica s poliklinikou F.D. Roosevelta

Banská Bystrica, 975 17, Slovakia

Institut nuklearnej a molekularnej mediciny

Banská Bystrica, 975 17, Slovakia

Bratislavske radiodiagnosticke centrum, a.s.

Bratislava, 814 99, Slovakia

CUIMED, s.r.o., Urologicka ambulancia

Bratislava, 851 05, Slovakia

Vychodoslovensky onkologicky ustav, a.s.

Košice, 041 91, Slovakia

Vychodoslovensky onkologicky ustav, a.s.

Košice, 04191, Slovakia

Institut nuklearnej a molekularnej mediciny

Košice, 042 53, Slovakia

Univerzitna nemocnica Martin

Martin, 036 59, Slovakia

IZOTOPCENTRUM, s.r.o.

Nitra, 949 01, Slovakia

Jessenius-diagnosticke centrum, a.s.

Nitra, 949 01, Slovakia

UROEXAM spol. s r.o. urologicka ambulancia

Nitra, 949 01, Slovakia

Alfamedis, s.r.o.

Prešov, 080 01, Slovakia

MILAB s.r.o., UROCENTRUM

Prešov, 080 01, Slovakia

Vivamed, s.r.o

Prešov, 080 01, Slovakia

UVN SNP - FN Ruzomberok, Pracovisko Nuklearnej mediciny CCSR

Ružomberok, 034 26, Slovakia

Fakultna nemocnica s Poliklinikou Skalica a.s

Skalica, 909 82, Slovakia

GAMMALAB, spol. s.r.o., Oddelenie nuklearnej mediciny

Trnava, 917 01, Slovakia

GAMMALAB, spol.s.r.o., Oddelenie nuklearnej mediciny

Trnava, 917 01, Slovakia

KK MED s.r.o.

Žilina, 010 01, Slovakia

Fakultna nemocnica s poliklinikou Zilina, Urologicke oddelenie

Žilina, 012 07, Slovakia

National Cancer Center

Goyang-si, Gyeonggi-do 10408, South Korea

Chonnam National University Hwasun Hospital

Hwasun-gun, Jeollanam-do 58128, South Korea

Gachon University Gil Medical Center

Incheon, 21565, South Korea

Seoul National University Hospital

Seoul, 03080, South Korea

Severance Hospital, Yonsei University Health System

Seoul, 03722, South Korea

Asan Medical Center

Seoul, 05505, South Korea

Gangnam Severance Hospital, Yonsei University Health System

Seoul, 06273, South Korea

Samsung Medical Center

Seoul, 06351, South Korea

Hospital Clinico Universitario de Santiago de Compostela

Santiago de Compostela, A Coruna 15706, Spain

Hospital Universitari Son Espases,

Palma de Mallorca, Balearic Islands 07010, Spain

Hospital Germans Trias i Pujol

Badalona, Barcelona 08916, Spain

ALTAHIA. Xarxa Assistencial Universitaria de Manresa

Manresa, Barcelona 08243, Spain

Hospital Universitario Parc Tauli

Sabadell, Barcelona 08208, Spain

ICO Girona-Hospital Universitari de Girona Dr. Josep Trueta

Girona, Catalonia 17007, Spain

Hospital de Navarra

Pamplona, Navarre 31008, Spain

Complejo Hospitalario Universitario A Coruna

A Coruña, 15006, Spain

Hospital Del Mar

Barcelona, 08003, Spain

Cetir Centre Medic, S.L.

Barcelona, 08029, Spain

Hospital Clinic de Barcelona

Barcelona, 08036, Spain

Hospital Universitario de la Princesa

Madrid, 28006, Spain

MD Anderson Cancer Center

Madrid, 28033, Spain

Hospital Universitario 12 de octubre

Madrid, 28041, Spain

Urologmottagningen

Gothenburg, 41345, Sweden

Diagnostiskt centrum for bild- och funktionsmedicin

Malmö, 205 02, Sweden

Urologiska Kliniken

Malmö, 20502, Sweden

Apoteket AB Kliniska Provningar Molnlycke

Mölnlycke, 435 33, Sweden

Urologiska Kliniken

Örebro, 70185, Sweden

Karolinska Universitetssjukhuset

Solna, 17164, Sweden

Urologmottagningen

Stockholm, 11853, Sweden

Urologkliniken

Umeå, 90185, Sweden

Chang Gung Medical Fundation, Chiayi Branch(Chiayi Chang Gung Memorial Hospital)

Chiayi County, 613, Taiwan

Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, 807, Taiwan

Kaohsiung Veterans General Hospital

Kaohsiung City, 81362, Taiwan

Chang Gung Medical Fundation,Kaohsiung (Kaohsiung Chang Gung Memorial Hospital)

Kaohsiung City, 830, Taiwan

Chang Gung Memorial Hospital, Keelung Branch (Keelung Chang Gung Memorial Hospital)

Keelung, 204, Taiwan

China Medical University Hospital

Taichung, 40447, Taiwan

Taichung Veterans General Hospital

Taichung, 40705, Taiwan

Chi Mei Medical Centre

Tainan, 710, Taiwan

National Taiwan University Hospital

Taipei, 100, Taiwan

Taipei Veterans General Hospital

Taipei, 11217, Taiwan

Chang-Gung Memorial Hospital at Linkuo

Taoyuan County, 333, Taiwan

Songklanagarind hospital

Hat Yai, Changwat Songkhla 90110, Thailand

Maharaj Nakorn Chiang Mai Hospital

Muang, Chiang Mai 50200, Thailand

King Chulalongkorn Memorial Hospital, Chulalongkorn University

Bangkok, 10330, Thailand

Rajavithi Hospital

Bangkok, 10400, Thailand

Cukurova Universitesi Tip Fakultesi

Adana, 01330, Turkey (Türkiye)

Hacettepe Universitesi Tip Fakultesi

Ankara, 06100, Turkey (Türkiye)

Istanbul Universitesi Cerrahpasa Tip Fakultesi

Istanbul, 34098, Turkey (Türkiye)

Izmir Bozyaka Egitim Arastirma Hastanesi

Izmir, 35170, Turkey (Türkiye)

Celal Bayar Universitesi Tip Fakultesi

Manisa, 45030, Turkey (Türkiye)

RCI Chernivtsi Regional Clinical Hospital

Chernivtsi, 58002, Ukraine

CI I.I. Mechnikov DRCH Dept of Urology #2

Dnipropetrovsk, 49005, Ukraine

CHI V.I.Shapoval RCC of Urology and Nephrology, Dep. Of Urology#4

Kharkiv, 61037, Ukraine

CNE Kyiv City Clinical Hospital #3 of Ex Body of KCC (Kyiv CSA), Department of Urology

Kyiv, 02125, Ukraine

Central City Clinical Hospital, City Oncological Center

Uzhhorod, 88000, Ukraine

CI Zaporizhzhia Regional Clinical Hospital, Dep. Of Urology,

Zaporizhzhya, 69600, Ukraine

East and North Hertfordshire NHS Trust

Northwood, Middlesex HA6 2RN, United Kingdom

Belfast Health and Social Care Trust

Belfast, Northern Ireland BT9 7AB, United Kingdom

Royal Marsden NHS Foundation Trust

Sutton, Surrey SM2 5PT, United Kingdom

The Newcastle upon Tyne Hospitals NHS Foundation Trust

Newcastle upon Tyne, TYNE and WEAR NE7 7DN, United Kingdom

University Hospitals Birmingham NHS Foundation Trust

Birmingham, B15 2TH, United Kingdom

University Hospitals Birmingham NHS Foundation Trust

Birmingham, B15 2WB, United Kingdom

University Hospitals Bristol NHS Foundation Trust

Bristol, BS2 8ED, United Kingdom

University Hospitals Bristol NHS Foundation Trust

Bristol, BS2 8HW, United Kingdom

Cambridge University Hospitals NHS Foundation Trust

Cambridge, CB2 0QQ, United Kingdom

University College Hospitals NHS Trust

London, NW1 2BU, United Kingdom

Imperial College Healthcare NHS Trust

London, W12 0HS, United Kingdom

University College London Hospitals NHS Foundation Trust

London, WC1E 6AG, United Kingdom

The Christie NHS Foundation Trust

Manchester, M20 4BX, United Kingdom

Oxford University Hospitals NHS Trust

Oxford, OX3 7LE, United Kingdom