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| Name | Class |
|---|---|
| University of Alberta | OTHER |
| Harvard Medical School (HMS and HSDM) | OTHER |
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Studies over the past two decades have convincingly demonstrated the role of barrier dysfunction in the pathogenesis of inflammatory bowel disease. It previously shown that optical biopsy with probe-based confocal laser endomicroscopy (pCLE) could be used to assess mucosal barrier function. Furthermore, mucosal barrier dysfunction on pCLE was shown to be predictive of disease relapse in adult IBD patients. The purpose of the current study is to determine the predictive value of pCLE findings in pediatric IBD patients.
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| Measure | Description | Time Frame |
|---|---|---|
| Primary study end-point was moderate to severe flare requiring hospitalization after pCLE | The purpose of the current study is to determine the predictive value of pCLE findings in pediatric IBD patients. | follow up period was a median of 18 months (range 4 to 33) |
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Inclusion Criteria:
Exclusion Criteria:
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Pediatric patients with IBD from all over Russia, treated from IBD in our Center
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| Name | Affiliation | Role |
|---|---|---|
| Andrey A Shavrov, M.D. | The Scientififc Center of Children's Health | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Scientific Center of Children's Health | Moscow | 119991 | Russia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26513619 | Derived | Shavrov A, Kharitonova AY, Davis EM, Claggett B, Morozov DA, Brown DK, Shavrov AA, Liu JJ. A Pilot Study of Confocal Laser Endomicroscopy to Predict Barrier Dysfunction and Relapse in Pediatric Inflammatory Bowel Disease. J Pediatr Gastroenterol Nutr. 2016 Jun;62(6):873-8. doi: 10.1097/MPG.0000000000001022. |
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| ID | Term |
|---|---|
| D015212 | Inflammatory Bowel Diseases |
| ID | Term |
|---|---|
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D007410 | Intestinal Diseases |
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Optical biopsy