Set the prospective cohort (CMERC-HI) to study the known and novel etiologies and related factors for predicting clinical outcomes in Korean patients with high risk cardiovascular disease.

Inclusion Criteria:

• high risk hypertension patients a. eGFR > 60 with one of target organ damages b. eGFR <= 60
• diabetes mellitus with microalbumin ration (AC ratio >= 30mg/g)
• anuric ESRD patients on dialysis
• the relatives of acute myocardial infarction patients under 55 years old (men)/ 65 years old (women)
• atherosclerotic cardiovascular disease (abdominal aorta diameter ≥3 cm or ankle-brachial index <0.9, or carotid plaque or carotid intima-media thickness ≥0.9 mm, or asymptomatic old cerebrovascular accident, or >30% stenosis in at least one major coronary artery)
• rheumatoid arthritis patients aged > 40 years on MTX and steroid therapy
• atrial fibrillation patients with CHADS-VASc Score ≥ 1
• kidney transplant recipient at > 3 months after transplantation

Exclusion Criteria:

• acute myocardial infarction, acute coronary syndrome patients, symptomatic coronary artery disease or history of these diseases
• symptomatic peripheral artery disease, heart failure and history of these diseases
• desired life time under 6 months due to non-cardiovascular disease (e.g. cancer, sepsis)
• women with pregnancy or on nursing
• history of contrast allergy and related side effects
• within the first three months after transplantation
• acute renal allograft rejection

high risk cardiovascular disease patients and their relatives