The purpose of this study is to investigate the association between the Independent Activities of Daily Living (I-ADL) component of the Comprehensive Geriatric Assessment (CGA) and poor tolerance to radiation treatment in older and younger patients with non-ovarian gynecological cancers.

There are little data regarding the impact of functional age on tolerance to radiotherapy for gynecologic cancers. A comprehensive geriatric assessment (CGA) tool which measures functional status (including the Instrumental Activities of Daily Living (I-ADL)), among many other important geriatric related conditions, was developed by Hurria and colleagues. Geriatric assessment variables including functional status predicted for toxicity in older patients receiving chemotherapy and surgery for multiple cancer types., 2 We hypothesize that I-ADL can be used to predict treatment tolerance in patients of all ages receiving pelvic and/or paraaortic region radiation therapy for gynecologic malignancies.

Inclusion Criteria:

• ≥Age 18 years (no upper age limit)
• Diagnosis of cervical, vaginal, vulvar, or endometrial cancer with either pelvic radiotherapy or chemoradiotherapy planned as part of standard treatment.
• Consented for receipt of External Beam Radiation Therapy (EBRT) at the University of North Carolina Chapel Hill
• Ability to read English (required for CGA)
• Curative treatment intent as defined by their radiation oncologist
• Negative serum pregnancy test in women of childbearing potential

Exclusion Criteria:

• < Age 18 years
• Incurable cancer as defined by their radiation oncologist
• Planned radiation for palliative intent only
• Inability to complete the I-ADL section of the CGA
• Prior radiation to areas targeted by radiotherapy within this study
• Other active, invasive malignancy requiring active ongoing therapy during their radiotherapy with the exception of:
• Localized squamous cell carcinoma of the skin
• Basal-cell carcinoma of the skin
• Other malignancies requiring locally ablative therapy only

Patients age 18 years of age or above with a diagnosis of cervical, vaginal, vulvar, or endometrial cancer with either pelvic radiotherapy or chemoradiotherapy planned as part of standard treatment with curative intent at the Department of Radiation Oncology at UNC Chapel Hill.