Adding Paracetamol to Ibuprofen for Treatment of Patent Ductus Arteriosus in Preterm Infants

Adding Paracetamol to Ibuprofen for Treatment of Patent Ductus Arteriosus in Preterm Infants: A Pilot, Double Blind, Randomized, Placebo-control Trial

The purpose of this study is to determine if adding paracetamol to ibuprofen is superior to ibuprofen only for treatment of patent ductus arteriosus (PDA) in preterm infants.

Randomized control trial to determine if adding paracetamol to ibuprofen is superior to ibuprofen only for treatment of patent ductus arteriosus (PDA) in preterm infants.

Inclusion Criteria:

• Preterm infants born at 24-37 gestational age
• diagnosis of Hemodynamically significant patent ductus arteriosus
• Medical staff decided to treat with Ibuprofen
• Parents have signed informed consent

Exclusion Criteria:

• Contraindication for ibuprofen
• Alanine transaminase /Aspartate transaminase≥ 200 U/L
• Significant congenital heart disease