Association Between CytochromeP4501A2 and CytochromeP4502E1 Gene Polymorphisms and Metabolism of Theophylline

Association Between CytochromeP4501A2(CYP1A2) and CytochromeP4502E1(CYP2E1) Gene Polymorphisms and Metabolism of Theophylline in a Chinese Population

The aim of this study is to determine whether common CYP1A2 and CYP2E1 gene polymorphisms effect metabolism of theophylline in chronic obstructive pulmonary disease patients.

Inclusion Criteria:

• Aged 18-75 years,COPD patients, male or female;
• regularly visiting our hospital;
• taking a sustained-release preparation of theophylline continuously for at least 2 weeks

Exclusion Criteria:

• patients with renal or hepatic dysfunction;
• patients with congestive heart failure;
• patients with hypothyroidism or hyperthyroidism;
• patients currently taking drugs likely to affect theophylline metabolism or who had taken such drugs in the preceding week;
• patients with extreme obesity
• patients with very severe Chronic Obstructive Pulmonary Disease(COPD)