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| ID | Type | Description | Link |
|---|---|---|---|
| 2013-001438-16 | EudraCT Number |
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| Name | Class |
|---|---|
| Unité de Soutien Méthodologique (CHU de La Réunion) | UNKNOWN |
| Hôpital Necker-Enfants Malades | OTHER |
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All adult patients with spontaneous cardiac activity and requiring tracheal intubation in the pre hospital emergency context will be included in order to compare the use of succinylcholine vs Rocuronium for prehospital emergency intubation.
All adult patients with spontaneous cardiac activity and requiring tracheal intubation in the pre hospital emergency context will be included. All intubation will be performed by an emergency physician or a nurse specialized in anesthesia. For patients with spontaneous cardiac activity, rapid sequence intubation will be performed to allow intubation.
Comparisons studied will be : Intubation success rate at the first laryngoscopy, glottis exposure assessed by Cormack and Lehane classification, difficult intubation rate assessed by the Intubation Difficult Score (IDS), the conditions of intubation assessed by the Copenhagen score, the need for alternative airway techniques and the immediate post intubation complications rate as vomiting, dental trauma, pulmonary inhalation, arterial desaturation , hypotension episodes and cardiac arrest occurrence.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Administration of Succinylcholine | Active Comparator | Intubation after IV administration of Succinylcholine 1mg/kg |
|
| Administration of Rocuronium | Experimental | Intubation after IV administration of Rocuronium 1.2 mg/kg |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Succinylcholine : 1mg/kg | Drug |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| First-pass intubation success rate | Measured by the proportion of successful intubation in the first laryngoscopy. | between 1 hour to 3 hours after inclusion |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of difficult intubation | measured by the Intubation Difficulty Scale | between 1 hour to 3 hours after inclusion |
| Intubation conditions assessment | using the Copenhagen score |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Xavier Combes, MD | CHU de La Réunion | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de La Réunion | Saint-Denis | La Réunion | 97405 | France | ||
| CHU de la Réunion |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31846014 | Derived | Guihard B, Chollet-Xemard C, Lakhnati P, Vivien B, Broche C, Savary D, Ricard-Hibon A, Marianne Dit Cassou PJ, Adnet F, Wiel E, Deutsch J, Tissier C, Loeb T, Bounes V, Rousseau E, Jabre P, Huiart L, Ferdynus C, Combes X. Effect of Rocuronium vs Succinylcholine on Endotracheal Intubation Success Rate Among Patients Undergoing Out-of-Hospital Rapid Sequence Intubation: A Randomized Clinical Trial. JAMA. 2019 Dec 17;322(23):2303-2312. doi: 10.1001/jama.2019.18254. |
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| Rocuronium : 1.2 mg/kg | Drug |
|
|
| between 1 hour to 3 hours after inclusion |
| Need for alternate airway devices | between 1 hour to 3 hours after inclusion |
| early intubation-related complications | complications : esophageal intubation, mainstem intubation, vomiting, pulmonary aspiration, dental trauma, bronchospasm or laryngospasm, ventricular tachycardia, arterial desaturation, hypotension, or cardiac arrest | between 1 hour to 3 hours after inclusion |
| Saint-Pierre |
| La Réunion |
| France |
| CHU Avicenne | Bobigny | France |
| CHU Henri Mondor | Créteil | France |
| CHU de Dijon | Dijon | France |
| CHU Raymond Poincaré | Garches | France |
| CH Gonesse | Gonesse | France |
| CHRU de Lille | Lille | France |
| CH Marc Jacquet | Melun | France |
| CHU de Nîmes | Nîmes | France |
| CHU Hôtel-Dieu | Paris | France |
| CHU Lariboisière | Paris | France |
| CHU Necker | Paris | France |
| CHU Pitié-Salpêtrière | Paris | France |
| CH René Dubos | Pontoise | France |
| CH Annecy | Pringy | France |
| CHU Toulouse - Hôpital PURPAN | Toulouse | France |
| ID | Term |
|---|---|
| D003128 | Coma |
| D004417 | Dyspnea |
| D012769 | Shock |
| ID | Term |
|---|---|
| D014474 | Unconsciousness |
| D003244 | Consciousness Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D012818 | Signs and Symptoms, Respiratory |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| D013390 | Succinylcholine |
| D000077123 | Rocuronium |
| ID | Term |
|---|---|
| D002794 | Choline |
| D050337 | Trimethyl Ammonium Compounds |
| D000644 | Quaternary Ammonium Compounds |
| D000588 | Amines |
| D009930 | Organic Chemicals |
| D013386 | Succinates |
| D003998 | Dicarboxylic Acids |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009861 | Onium Compounds |
| D000732 | Androstanols |
| D000731 | Androstanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
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