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Parkinson's disease (PD) is the second most prevalent neurodegenerative disease. The investigators clinical experience showed a trend of delayed emergence among patients undergoing deep brain stimulator (DBS) implantation and pulse generator placement under general anesthesia. Abnormal pharmacodynamics might be present among these patients, which had never been investigated.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PD group | Patients with Parkinson's disease undergoing deep brain stimulator implantation and pulse generator placement | ||
| non-PD group | Patients without Parkinson's disease undergoing intracranial surgery |
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| Measure | Description | Time Frame |
|---|---|---|
| Consciousness status | Consciousness status is evaluated by the observer's assessment of alertness and sedation score (OAA/S). | Participants will be monitored during the period of propofol infusion, an expected average of less than 10 min |
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Inclusion Criteria:
Exclusion Criteria:
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Our study recruits patients with Parkinson's disease undergoing deep brain stimulator implantation and pulse generator placement under general anesthesia and non-Parkinsonian patients without Parkinson's disease undergoing intracranial surgery under general anesthesia
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| Name | Affiliation | Role |
|---|---|---|
| Jia-feng Wang, M.D. | Department of Anesthesiology, Changhai Hospital, Second Military Medical University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesiology, Changhai Hospital | Shanghai | Shanghai Municipality | 200433 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26495319 | Derived | Xu XP, Yu XY, Wu X, Hu XW, Chen JC, Li JB, Wang JF, Deng XM. Propofol requirement for induction of unconsciousness is reduced in patients with Parkinson's disease: a case control study. Biomed Res Int. 2015;2015:953729. doi: 10.1155/2015/953729. Epub 2015 Oct 1. |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |