Individualized Nutritional Counselling During Chemotherapy for Colorectal Cancer (COLONUT)

The Effect of Individualized NUTritional Counselling on Muscle Mass and Treatment Outcome in Patients With Metastatic COLOrectal Cancer Undergoing Chemotherapy: the COLONUT Study

The purpose is to study the effect of individualized nutritional counselling compared to usual nutritional care on cross-sectional muscle area in patients with stage IV colorectal cancer during first line chemotherapy. Secondary, effect on total lean body mass, treatment intensity, physical functioning, quality of life and survival will be studied.We hypothesize that patients in the intervention arm benefit from individualized nutritional counseling.

Inclusion Criteria:

• Age ≥18 years
• Stage IV colorectal cancer
• Scheduled for treatment with first line chemotherapy, either CAPOX(-B), FOLFOX(-B) or capecitabine(-B)
• CT scan suitable for evaluating muscle mass at L3 level
• Understanding of the Dutch language
• Able and willing to give written informed consent

Exclusion Criteria:

• Chemotherapy in the previous three months
• WHO performance status ≥ 3
• Long-term high dose of corticosteroids: ≥ three weeks ≥ ten milligram prednisolon or equivalent