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| Name | Class |
|---|---|
| Ministry of Health & Welfare, Korea | OTHER_GOV |
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To explore electrophysiologic parameters and biomarkers predicting treatment response of patients with major depressive disorder To explore electrophysiologic parameters and biomarkers predicting suicide risk of patients with major depressive disorder
Case-control study Repeated measures design
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Escitalopram | Experimental | depressed patients receiving escitalopram treatment |
|
| Control | No Intervention | healthy controls matched for age, gender, and BMI |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| escitalopram | Drug | SSRI antidepressant |
|
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| Measure | Description | Time Frame |
|---|---|---|
| Change in baseline frequency of maximum of cross-spectrum during 6 weeks (Hz) | the link between the normalized high frequency component of heart rate variability (HRV-HFnu) representing cardiac vagal modulation and frontal alpha power related to resting state | 0, 3, 7, 14, and 42 days |
| Measure | Description | Time Frame |
|---|---|---|
| Change in cardiorespiratory coupling during 6 weeks | change in value of cross-sample entropy measured by combining sample entropies of heart rate and respiration | 0, 3, 7, 14, and 42 days |
| Change in HF during 6 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jae Seung Chang, MD, PhD | Contact | 82-31-787-7437 | cjs0107@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Jae Seung Chang, MD, PhD | Seoul National University Bundang Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Bundang Hospital | Recruiting | Seongnam-si | Gyeonggi-do | 463-707 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22408133 | Background | Chang JS, Yoo CS, Yi SH, Her JY, Choi HM, Ha TH, Park T, Ha K. An integrative assessment of the psychophysiologic alterations in young women with recurrent major depressive disorder. Psychosom Med. 2012 Jun;74(5):495-500. doi: 10.1097/PSY.0b013e31824d0da0. Epub 2012 Mar 9. |
| Label | URL |
|---|---|
| health information about depression | View source |
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| ID | Term |
|---|---|
| D003865 | Depressive Disorder, Major |
| D003863 | Depression |
| ID | Term |
|---|---|
| D003866 | Depressive Disorder |
| D019964 | Mood Disorders |
| D001523 | Mental Disorders |
| D001526 | Behavioral Symptoms |
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| ID | Term |
|---|---|
| D000089983 | Escitalopram |
| ID | Term |
|---|---|
| D011437 | Propylamines |
| D000588 | Amines |
| D009930 | Organic Chemicals |
| D009570 | Nitriles |
| D001572 |
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change in high frequency component of heart rate variability
| 0, 3, 7, 14, and 42 days |
| Change in persistent homology during 6 weeks | change in disconnection pattern of EEG channel activities measured by Euclidean distance during 6 weeks | 0, 3, 7, 14, and 42 days |
| D001519 |
| Behavior |
| Benzofurans |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |