Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Ubberup Folk High School | OTHER |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
In Denmark and the western world, there is an increasing prevalence of obesity probably due to a combination of inadequate daily physical activity and a high energy intake. One approach to achieve weight loss and change life style is to participate in an intensive supervised prolonged life style modification course. The immediate effect is often positive, but over time the overall effect is limited as the majority will not maintain weight loss and a changed life style.
The purpose of this study is therefore to characterize the physiological factors that determine/influence the capacity to maintain weight loss and a healthy lifestyle after a prolonged lifestyle intervention.
The investigators have the following research questions:
The study design is cross-sectional and will be based on a lifestyle intervention, as it is practiced in a real life setting at Ubberup folk high school. The investigators will recruit former participants of this lifestyle style intervention. 50 % who maintained a weight loss and a healthy life style and 50 % who did not.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intensive Lifestyle Intervention | Former participants of Ubberup Folk High Schools intensive lifestyle intervention programme. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intensive Lifestyle Intervention | Behavioral | The included subjects has previously participated in the Intensive Lifestyle Intervention intervention at Ubberup Folk High School. This intervention includes daily exercise and a hypocaloric diet (app. -700KCal/day) for 10-14 weeks. Furthermore theoretical and practical education within e.g. Nutrition, exercise and motivational psychology. |
| Measure | Description | Time Frame |
|---|---|---|
| Total Body weight | 0-14 years after the intervention is completed |
| Measure | Description | Time Frame |
|---|---|---|
| Anthropometry | Body composition measured by dual x-ray absorptiometry or bio-impedance, height, weight, waist circumference. | 0-14 years after the intervention is completed |
| Maximal fat oxidation |
| Measure | Description | Time Frame |
|---|---|---|
| Adherence to a healthy diet | Questionnaire (24hrs dietary recall) and diary to determine adherence to a healthy diet | 0-14 years after the intervention is completed |
| Adherence to physical activity | International Physical Activity Questionnaire (IPAQ) to determine adherence to physical activity. Furthermore we will use diary and ActiHeart (accelerometer). |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Former participants of Ubberup Folk High School will be included in this study. Ubberup Folk High School is a privately hold externate that teaches lifestyle intervention courses with focus on weight loss. A stay at Ubberup has a duration of 10-14 weeks and is primarily self-financed. The study population will consist of men and women of two different age Groups (18-35 and 35-65yr). We will recruit participants who succeeded in maintaining the weight loss and participants who regained in weight.
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Jørn W Helge, PhD | University of Copenhagen, Department of Biomedical Sciences | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Copenhagen, Department of Biomedical Sciences | Copenhagen | 2200 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24090083 | Background | Karlsen TI, Sohagen M, Hjelmesaeth J. Predictors of weight loss after an intensive lifestyle intervention program in obese patients: a 1-year prospective cohort study. Health Qual Life Outcomes. 2013 Oct 3;11:165. doi: 10.1186/1477-7525-11-165. | |
| 23801526 | Background | McCormack SE, McCarthy MA, Harrington SG, Farilla L, Hrovat MI, Systrom DM, Thomas BJ, Torriani M, McInnis K, Grinspoon SK, Fleischman A. Effects of exercise and lifestyle modification on fitness, insulin resistance, skeletal muscle oxidative phosphorylation and intramyocellular lipid content in obese children and adolescents. Pediatr Obes. 2014 Aug;9(4):281-91. doi: 10.1111/j.2047-6310.2013.00180.x. Epub 2013 Jun 25. |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D009765 | Obesity |
| D050177 | Overweight |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
Not provided
Not provided
Not provided
Not provided
Not provided
Whole blood, muscle and fat tissue.
|
Respiratoric Exchange Ratio (RER) is measured during an incremental cycling test and maximal fat oxidation is calculated
| 0-14 years after the intervention is completed |
| Maximal Oxygen Consumption | 0-14 years after the intervention is completed |
| 0-14 years after the intervention is completed |
| Mitochondria respiration and efficiency | Mitochondria respiration and efficiency measured by Oreboros Oxygraph | 0-14 years after the intervention is completed |
| Blood and plasma substrates, hormones and metabolites | HbA1c, insulin, leptin, glucose, adiponectin, thyroid stimulating hormone (TSH), Ghrelin. | 0-14 years after the intervention is completed |
| Muscle lipid composition | Muscle lipid composition will be analyzed using a lipidomics approach. | 0-14 years after the intervention is completed |
| Expression of muscle lipases | Western Blot analyses will be Applied to analyse expression of muscle lipases; hormone sensitive lipase (HSL), adipose triglyceride lipase (ATGL) and lipoprotein lipase (LPL) as well muscle PAT proteins; PLIN 2 (ADRP), PLIN 3 (TIP47) and PLIN5 (OXPAT) | 0-14 years after the intervention is completed |
| Adipose tissue macrophage inflammation and cytokine production | 0-14 years after the intervention is completed |
| Intramuscular lipid droplet content and size, glycogen content and ceramide content and location | Intramuscular lipid droplet content and size, glycogen content and ceramide content and location wil be quantified by immunohistochemical staining of serial cryo-sections of muscle tissue samples that are visualized by confocal microscopy | 0-14 years after the intervention is completed |
| Motivation for lifestyle changes and sociological factors involved | Questionnaires | 0-14 years after the intervention is completed |
| 23710347 | Background | Danielsen KK, Svendsen M, Maehlum S, Sundgot-Borgen J. Changes in body composition, cardiovascular disease risk factors, and eating behavior after an intensive lifestyle intervention with high volume of physical activity in severely obese subjects: a prospective clinical controlled trial. J Obes. 2013;2013:325464. doi: 10.1155/2013/325464. Epub 2013 Apr 22. |
| 16352667 | Background | Bruun JM, Helge JW, Richelsen B, Stallknecht B. Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects. Am J Physiol Endocrinol Metab. 2006 May;290(5):E961-7. doi: 10.1152/ajpendo.00506.2005. Epub 2005 Dec 13. |
| 16403343 | Background | Pedersen JO, Zimmermann E, Stallknecht BM, Bruun JM, Kroustrup JP, Larsen JF, Helge JW. [Lifestyle intervention in the treatment of severe obesity]. Ugeskr Laeger. 2006 Jan 9;168(2):167-72. Danish. |
| 17893261 | Background | Bruun JM, Stallknecht B, Helge JW, Richelsen B. Interleukin-18 in plasma and adipose tissue: effects of obesity, insulin resistance, and weight loss. Eur J Endocrinol. 2007 Oct;157(4):465-71. doi: 10.1530/EJE-07-0206. |
| 17299115 | Background | Christiansen T, Bruun JM, Madsen EL, Richelsen B. Weight loss maintenance in severely obese adults after an intensive lifestyle intervention: 2- to 4-year follow-up. Obesity (Silver Spring). 2007 Feb;15(2):413-20. doi: 10.1038/oby.2007.530. |
| 30024231 | Derived | Elsborg P, Elbe AM. Exercise-specific volition and motivation for weight loss maintenance following an intensive lifestyle intervention. Health Psychol. 2018 Aug;37(8):759-766. doi: 10.1037/hea0000636. |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |