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The primary objective is to compare the difference in the pain score in radial arterial puncture using the insulin needle versus the standard 23G hypodermic needle.
In a randomised, crossover design, healthy volunteers were recruited to receive bilateral radial arterial punctures. They were assigned to receive either the insulin or the standard needle as the first puncture using block randomisation. The primary outcome was the pain score measured on a 100mm visual analogue scale (VAS) and the secondary outcomes were procedural complications and rate of haemolysis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Insulin | Experimental | Arterial puncture with an insulin syringe followed by arterial puncture with standard needle. |
|
| Standard | Active Comparator | Arterial puncture with standard needle followed by arterial puncture with insulin syringe. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Standard needle BBraun Sterican® 23G and 25mm in length | Device | Arterial puncture using the hypodermic needle (BBraun Sterican® 23G and 25mm in length) attached to a 3 ml syringe. |
| Measure | Description | Time Frame |
|---|---|---|
| Visual analogue scale (VAS) score in millimetres | Immediately following the radial arterial punctures the outcome assessor asked the volunteer to assess the discomfort that was caused by the puncture. The volunteer was asked to place a slash on a 100 mm VAS sheet. The VAS showed "no pain" at 0 mm and "worst pain" at 100 mm. | Immediately after each puncture ( average within 5 minutes) |
| Measure | Description | Time Frame |
|---|---|---|
| blood haemolysis | The serum collected during the punctures was analysed for the amount of free haemoglobin. We define presence of haemolysis as free haemoglobin concentration of more than 100 mg/dL. | Immediately after collection |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Irwani Ibrahim, MBBS | National Unversity Health Systems | Principal Investigator |
| Yau Ying Wei, MBBS | National University Health Systems | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National University Hospital | Singapore | Singapore | 119074 | Singapore |
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| ID | Term |
|---|---|
| D010146 | Pain |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D007332 | Insulin Infusion Systems |
| ID | Term |
|---|---|
| D016503 | Drug Delivery Systems |
| D004358 | Drug Therapy |
| D013812 | Therapeutics |
| D007260 | Infusion Pumps |
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| Insulin | Device | Arterial puncture using the insulin syringe (Terumo®- 0.5 ml with attached needle 29G and 13mm in length) |
|
| D004864 |
| Equipment and Supplies |
| D001187 | Artificial Organs |
| D013523 | Surgical Equipment |