Radiofrequency-assisted Hepatectomy on the Outcomes of HCC Patients With Cirrhosis

The Influence of Radiofrequency-assisted Hepatectomy on the Perioperative Outcomes and the Long-term Prognosis of HCC With Cirrhosis：A Prospective Randomized Controlled Trial

Surgical resection is the most effective treatment of primary and secondary liver tumors. Technical innovations have mainly focused on minimizing bleeding during transection of the hepatic parenchyma because excessive hemorrhage and the need for blood transfusion are associated with increased postoperative morbidity and mortality. Recently,radiofrequency-assisted（RFA）hepatectomy has developed rapidly and gained widespread acceptance for the treatment of hepatocellular carcinomas（HCC），but its influence on the prognosis of HCC patients，especially for those with cirrhosis，is still controversial. Therefore, we design this prospective clinical trial to explore the effect of RFA hepatectomy versus the conventional hepatectomy on the outcomes of perioperative period and prognosis of HCC patients with cirrhosis.

Inclusion Criteria:

• Aged from 18 to 65 years , no gender restriction.
• Clinical diagnosis of resectable HCC.
• Preoperative liver function test showed Child-Pugh Class A or B.
• Indocyanine green retention at 15 minutes (ICG-15) of <30%.
• Acceptable clotting profile :platelet count > 50 x 109/L and a prolonged prothrombin time of < 5 seconds.
• Enough relative residual liver volume (%RLV) ≥ 40%.
• No tumor invasion in primary branch of portal vein, hepatic vein, or inferior vena cava.
• No other anti-tumor therapy received before the treatment.
• No metastasis in lymphnode or other organs.
• Written consent inform assigned.

Exclusion Criteria:

• Pregnancy.
• Intraoperative findings of tumor rupture，extrahepatic tumor or lymphnode metastasis.
• Tumor invasion in primary branch of portal vein, hepatic vein, or inferior vena cava.