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| ID | Type | Description | Link |
|---|---|---|---|
| 12411950500 | Other Grant/Funding Number | Science and Technology Commission of Shanghai Municipality |
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Acute lung injury (ALI) and acute respiratory distress syndrome(ARDS) represent the most common and earliest organ dysfunction in acute pancreatitis, presenting as dyspnea and intractable hypoxemia, with secondary bilateral pulmonary infiltrates on radiograph. And mechanical ventilation (MV) is the essential intervention to improve oxygenation. When to initiate MV remains uncertain. In this study, we aim to compare the effect of early MV and conventional MV, and we hypothesize that early MV may be a better treatment option.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| early mechanical ventilation | Experimental | Fulfillment of three or more criteria below: respiratory rate > 28 per minute serum lactate > 3 mmol/L PaO2/FiO2 Index <300 mmHg SvO2 < 65% lung infiltration or atelectasis, pleural exudation Abbreivation: PaO2, arterial partial pressure of oxygen; FiO2, fraction of inspired oxygen; SvO2, venous oxygen saturation |
|
| conventional mechanical ventilation | Experimental | other group who don't start early mechanical ventilation and fulfillment four criteria below: respiratory rate > 28 bpm dyspnea PaO2/FiO2 Index <200 mmHg Chest X-ray: lung infiltration exclude chronic heart failure and pulmonary disease |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| early mechanical Ventilation | Other | Fulfillment of three or more criteria below: respiratory rate > 28 per minute serum lactate > 3 mmol/L PaO2/FiO2 Index <300 mmHg SvO2 < 65% lung infiltration or atelectasis, pleural exudation |
| Measure | Description | Time Frame |
|---|---|---|
| Mechanical Ventilation Time | 28 days |
| Measure | Description | Time Frame |
|---|---|---|
| the incidence of ventilation associated pneumonia | 28 days |
| Measure | Description | Time Frame |
|---|---|---|
| mortality | 60 days | |
| the incidence other complications of mechanical ventilation | patient-mechanic desynchronization, pneumothorax, atelectasis | participants will be followed for the duration of hospital stay, an expected average of 2 months |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Erzhen CHEN, MD | Contact | 86-13901753478 | chenerzhen@hotmail.com | |
| Enqiang MAO, MD | Contact | 86-13501747906 |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of EICU, Ruijin Hospital | Recruiting | Shanghai | 200025 | China |
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| ID | Term |
|---|---|
| D010195 | Pancreatitis |
| ID | Term |
|---|---|
| D010182 | Pancreatic Diseases |
| D004066 | Digestive System Diseases |
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| Conventional Mechanical Ventilation | Other | other group who don't start early mechanical ventilation and fulfillment four criteria below: respiratory rate > 28 bpm dyspnea PaO2/FiO2 Index <200 mmHg Chest X-ray: lung infiltration exclude chronic heart failure and pulmonary disease |
|
| hospital stay | the participants will be followed till the discharge, an expected average of 2 months |