Suitability of DCE-MRI for Detection of Vascular Changes After VBT

A Pilot Study to Assess the Suitability of DCE-MRI for Detection of Vascular Changes After Vaginal Brachytherapy

This is a pilot study of DCE MR imaging to detect vascular changes in the vagina during and after radiotherapy n patients receiving adjuvant brachytherapyfor cervical or endometrial cancer.

Inclusion Criteria:

• Must be 18 years of age.
• Must have histologically confirmed carcinoma of the cervix, carcinoma or carcinosarcoma of the uterus.
• Subjects are receiving intracavitary brachytherapy.
• ECOG performance status of 0-2.
• Creatinine clearance 30.

Exclusion Criteria:

• Subjects with an inability to tolerate MR imaging (i.e. claustrphobia)
• Study subjects who have contraindication to MRI scanning such as but not limited to subjects with pacemakers, metal fragments in the eye or certain metallic implants.
• Patients who do not speak or read English.