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| Name | Class |
|---|---|
| St. Olavs Hospital | OTHER |
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The purpose of this study is to examine whether exercise reduces the postprandial effects of an unhealthy meal on heart function and endothelial function.
Both healthy people and type 2 diabetes subjects will during three days either carry out two different sessions of exercise training or not before ingesting an unhealthy meal high in saturated fat and fast carbohydrates. The two different exercise training modes used are high intensity interval training (HIIT) and moderate intensity training (MIT) Hypothesis: Exercise training in advance of an unhealthy meal will improve endothelial- and cardiac function in healthy and type 2 diabetes individuals. HIIT will reduce the negative postprandial effects on the endothelium more than MIT.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| exercise diabetes type 2 | Experimental | 4x4 min interval training, 47 min moderate intensity training, or no exercise preceding an 'unhealthy' meal. |
|
| exercise healthy volunteers | Active Comparator | 4x4 min interval training, 47 min moderate intensity training, or no exercise preceding an 'unhealthy' meal. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 47 min moderate intensity training | Behavioral |
| ||
| exercise healthy volunteers |
| Measure | Description | Time Frame |
|---|---|---|
| endothelial function | measured as flow mediated dilatation (FMD) of the brachial artery using high resolution vascular ultrasound according to current guidelines | 24 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Charlotte B Ingul, PhD | Norwegian University of Science and Technology | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Forskningsposten, St Olavs Hospital | Trondheim | Norway | ||||
| ISB |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26272328 | Result | Hollekim-Strand SM, Malmo V, Follestad T, Wisloff U, Ingul CB. Fast food increases postprandial cardiac workload in type 2 diabetes independent of pre-exercise: A pilot study. Nutr J. 2015 Aug 14;14:79. doi: 10.1186/s12937-015-0069-1. |
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| Behavioral |
|
| control; no exercise training | Behavioral |
|
| Trondheim |
| Norway |
| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D001519 | Behavior |
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