Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| dsm-firmenich Switzerland AG | INDUSTRY |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Previous studies on iron absorption have focused on the effects on the addition of iron absorption enhancers like ascorbic acid and EDTA to a meal and more recently the enzymatic phytic acid removal through phytase. The investigators want here to investigate the effects of fat on iron absorption with and without the addition of exogenous phytase as a potential iron absorption enhancer in lipid nutrient supplements (LNS) products compared to micronutrient powder(MNP) products.
Furthermore the investigators will evaluate the effects of Lipids- on iron absorption to induce the ileal brake by ingestion of a fat emulsion prior to a meal. Increasing the caloric density of a meal by increasing its fat content might enhance iron absorption by delaying gastric emptying, gastric acid secretion and increasing Fe stomach residence time.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| LNS | Other | Maize meal mixed with Lipid Nutrient Supplement (LNS) containing micronutrient powder |
|
| FePP-Emulsion mixed | Other | Fat emulsion mixed to the meal containing FePP |
|
| FeSO4-Mixed | Other | meals containing FeSO4 mixed with a fat emulsion |
|
| FePP-Emulsion before | Other | Fat emulsion taken before a meal containing FePP |
|
| FeSO4- Emulsion before | Other | Fat emulsion taken before a maize meal containing FeSO4 |
|
| LNS-Phytase | Other | Maize meal mixed with LNS containing micronutrient powder and phytase |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| micronutrient powder | Dietary Supplement |
| ||
| micronutrient powder (containing FeSO4), phytase |
| Measure | Description | Time Frame |
|---|---|---|
| Iron bio-availability from Oral Iron Supplements | Iron bioavailability will be assessed with stable isotopic labels. The shift in the isotopic ratio in human whole blood 14 days after administration will be measured with mass spectrometry. | 14 days |
Not provided
Not provided
Inclusion Criteria:
Reproductive age females 18-45 years
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Michael B Zimmermann, Prof | ETH Zürich | Principal Investigator |
Not provided
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28468891 | Derived | Monnard A, Moretti D, Zeder C, Steingotter A, Zimmermann MB. The effect of lipids, a lipid-rich ready-to-use therapeutic food, or a phytase on iron absorption from maize-based meals fortified with micronutrient powders. Am J Clin Nutr. 2017 Jun;105(6):1521-1527. doi: 10.3945/ajcn.116.142976. Epub 2017 May 3. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
|
| phytase | Other | Maize meal containing micronutrient powder and phytase |
|
| MNP-control | Other | maize meal containing micronutrient powder (MNP) |
|
| FePP control | Other | Maize meal containing FePP |
|
| FeSO4 control | Other | Maize meal containing FeSO4 |
|
| Dietary Supplement |
|
| Iron pyrophosphate (FePP) | Dietary Supplement |
|
| Iron sulphate | Dietary Supplement |
|
| ID | Term |
|---|---|
| D000090463 | Iron Deficiencies |
| ID | Term |
|---|---|
| D019189 | Iron Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D010832 | 6-Phytase |
| D007505 | Iron-Dextran Complex |
| ID | Term |
|---|---|
| D010744 | Phosphoric Monoester Hydrolases |
| D004950 | Esterases |
| D006867 | Hydrolases |
| D004798 | Enzymes |
| D045762 | Enzymes and Coenzymes |
| D056831 | Coordination Complexes |
| D009930 | Organic Chemicals |
| D003911 | Dextrans |
| D005936 | Glucans |
| D011134 | Polysaccharides |
| D002241 | Carbohydrates |
Not provided
Not provided