Response to NonInvasive Mechanical Ventilation According to the Breathing Pattern

Response to NonInvasive Mechanical Ventilation According to the Breathing Pattern

The purpose of this study is to determine whether breathing pattern (specifically the inspiratory time/total respiratory cycle value) has an influence over the response to the noninvasive mechanical ventilation.

Breathing pattern will be analyzed along the adaptation to 3 different NonInvasive-Mechanical-Ventilation modes (controlled mode, spontaneous mode and placebo mode or simulator).

Inclusion Criteria:

• Hypercapnic chronic respiratory failure due to restrictive pulmonary disease (with usual criteria for home NonInvasive Mechanical Ventilation).
• Transcutaneous carbon dioxide (CO2) basal pressure ≥ 50 mmHg when conscious.
• Clinically stable (within the previous month).
• Patients without previous NonInvasive Mechanical Ventilation treatment.

Exclusion Criteria:

• Clinical exacerbation.
• Chronic airflow limitation Forced expiratory volume in 1 second/Forced vital capacity (FEV1/FVC) ratio < 70% or Sleep Apnea-Hypopnea Syndrome