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The study purpose is to examine polymorphism of genes associated to post-operative persistent pain and to verify the possible association between genotype phenotype and ADRB2 polymorphism in orthopaedic surgery. The primary aim is to evaluate the expression of ADBR2 in VAS>4 patients and to compare it to those with VAS<4.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| VAS<4 | |||
| VAS>4 |
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| Measure | Description | Time Frame |
|---|---|---|
| Frequency of SNPs rs12654788 and rs1042713 of ADBR2 gene in patients who complain persistent pain 4 months postoperatively compared to chronic pain free patients. | 4 months after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Expression frequency of OPRM1, COMT, IL1Ra | 6, 12, 24, 48 hours | |
| Serum concentration of TNFα, TGFβ, IFNγ, IL-6 and IL-10 obtained with ELISA system | 6, 12, 24 and 48 hours postoperatively |
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Inclusion Criteria:
Exclusion Criteria:
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Patients undergoing total knee arthoplasty.
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| Name | Affiliation | Role |
|---|---|---|
| Gianluca Cappelleri, MD | ASST Gaetano Pini-CTO | Principal Investigator |
| Manuela de Gregori, Biologist | Fondazione IRCCS Policlinico San Matteo di Pavia | Study Chair |
| Massimo Allegri, M.D. | Fondazione IRCCS Policlinico San Matteo di Pavia | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Istituto Ortopedico G. Pini | Milan | Milano | 20122 | Italy |
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| ID | Term |
|---|---|
| D059350 | Chronic Pain |
| ID | Term |
|---|---|
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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Blood plasma