The purpose of this study is to evaluate efficacy of biomarker in patient with interstitial cystitis/painful bladder syndrome

This is a observational study

Inclusion Criteria:

• 1) must have experienced bladder pain, urinary urgency and urinary frequency, for at least 6 months prior to entry into the study 2) Pain VAS ≥4 3) O'Leary-Sant Interstitial Cystitis questionnaire (IC-Q) symptom and problem ≥ 12( and pain ≥2, and nocturia ≥ 2) 4) PUF score ≥ 13 5) cystoscopic record within 2 years

Exclusion Criteria:

1. Patients who are pregnancy or, childbearing age without no contraception

2. Patients with voided volume <40 or, > 400ml

3. Patients with microscopic hematuria, (≥1+ in dipstick), If not excluded that no evidence of neoplastic tumor examination

4. Patients with urine culture showing evidence of urinary tract infection 1month prior to the study

5. Accompanied medical problem below

   • Tuberculosis in urinary system
   • Bladder cancer, urethral cancer, prostate cancer
   • Recurrent cystitis
   • anatomical disorder

6. Patients had prior surgery (eq, bladder augmentation, cystectomy

7. Patients with neurologic disorder

8. Patients with indwelling catheter or intermittent self-catheterization

9. Patients with psychologic problem

patients >20 years old with interstitial cystitis control