Utrogestan Versus Nifedipine as Tocolysis for Preterm Labor: a Randomised Controlled Trial

STUDY ON EFFICACY OF UTROGESTAN AS TOCOLYSIS FOR PRETERM LABOR

RESEARCH HYPOTHESIS

-Incidence of preterm delivery is lower in women treated with oral micronized progesterone (Utrogestan) as acute tocolysis agent compare to Nifedipine group with fewer maternal side effect

Inclusion Criteria:

• Singleton pregnancy women between 22 and 34 weeks of gestation who presented with threatened preterm labor.

Exclusion Criteria:

• Multiple pregnancies
• Women with Preterm Prelabour Rupture of Membrane
• Fetal death
• Women with bad obstetric history
• Women with history of cervical incompetence
• Contraindication to Nifedipine such as cardiovascular disease, hyperthyroidism, severe pre eclampsia or to Utrogestan
• Maternal or fetal indication for immediate delivery, such as fetal distress, bleeding placenta previa, abruption placenta
• Contraindication for tocolysis, for example severe pre eclampsia, intrauterine growth restriction, fetal anomaly, chorioamnionitis, significant antepartum haemorrhage
• Cervical dilatation of 3cm or more
• Patients with previous tocolytic treatment during this pregnancy
• Women who refuse to participate in this study