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| ID | Type | Description | Link |
|---|---|---|---|
| TRRFLC1 | Other Identifier | HunanPTH |
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In pre-clinical study the investigators found that the thioredoxin reductase activity of serum harbours huge difference between cancer patients and non-cancer patients, the enzyme activity elevated remarkably among cancer patients, so the investigators hypothesis that this is due to tumor cells loading of the patients, the enzyme activity may harbours huge difference between carcinoma tissues and para-carcinoma tissues in early staged non-small cell lung cancers, and after surgery, the enzyme activity may fall down to a normal level because of removing of tumor.
This is a cooperative research project in Thoracic Surgery Department and Medical Oncology Department of Affiliated Cancer Hospital of xiangya School of Medicine Central South University, and the State Key Laboratory for Natural Medicine and Biomimetic Drugs Perking University. The primary objective is to measure the thioredoxin reductase activity using blood and lung cancer tissue and measure thioredoxin reductase messenger ribonucleic acid (mRNA) and protein expression using lung cancer and pericarcinomatous tissue in early staged(â… ~â…¢A) non-small lung cancers, to study the correlations of thioredoxin reductase between blood and tissue. The secondary objectives are to measure the thioredoxin reductase activity between non small lung cancers and lung benign lesion patients to identify the difference between tumor and lung benign mass.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| early staged non-small cell lung cancers | patients who diagnosed as early staged non-small cell lung cancer after surgery | ||
| lung benign mass patients | patients who diagnosed as lung benign mass after surgery |
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| Measure | Description | Time Frame |
|---|---|---|
| measure the thioredoxin reductase activity in blood, tumor and pericarcinomatous tissue | 3-4 ml blood should be taken and centrifuged in 30 mins, then the serum should be stored at -20 degree, then serum thioredoxin reductase activity should be measured in one month. Tumor and pericarcinomatous tissues should be stored at -180 degree and enzyme activity should be measured within one month | blood should be taken in 2 days before surgery, tumor and pericarcinomatous tissues should be stored and tested in one month |
| Measure | Description | Time Frame |
|---|---|---|
| Measure the difference of thioredoxin reductase activity between lung cancer tissue and lung benign mass | Tumor tissue or lung benign mass obtained during surgery should be stored at -180 degree within 5 mins and enzyme activity should be measured within one month. | Tumor tissue or lung benign mass obtained during surgery should be stored at -180 degree within 5 mins and enzyme activity should be measured within one month |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with early staged NSCLC and lung benign lesion Patients show resectable lung mass in CT scan, suspected lung cancer and receive surgery in Affiliated Cancer Hospital of Xiangya School of Medicine Central South University
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| Name | Affiliation | Role |
|---|---|---|
| Nong Yang, MD | Hunan Province Tumor Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hunan Provincal Tumor Hospital | Changsha | Hunan | 410013 | China |
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| ID | Term |
|---|---|
| D002289 | Carcinoma, Non-Small-Cell Lung |
| ID | Term |
|---|---|
| D002283 | Carcinoma, Bronchogenic |
| D001984 | Bronchial Neoplasms |
| D008175 | Lung Neoplasms |
| D012142 | Respiratory Tract Neoplasms |
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tumor tissue and lung benign mass are obtained in surgery, and blood serum before surgery and 3-5 days after surgery, blood should be taken and centrifuged then stored at -20 degree, tumor tissue and lung benign mass should be stored at -180 degree within 5 mins during surgery.
| Measure the thioredoxin reductase mRNA and protein expression in tumor and pericarcimomatous tissue | Tumor tissue or pericarcimomatous tissue should be stored at -180 degree, then qRT-PCR should be done within 3 months | Tumor tissue or pericarcimomatous tissue should be stored at -180 degree, then qRT-PCR should be done within 3 months |
| D013899 |
| Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |