Differential Study of Muscle Transcriptome

Differential Study of Muscle Transcriptome in Patients With Neuromuscular Disease and Control Subjects

To isolate biomarkers of ALS in muscle

At present, there is no validated biological diagnostic marker for amyotrophic lateral sclerosis (ALS). The main objective of the study is to isolate a set of genes that are specifically dysregulated in muscle from ALS patients.

Gene profiling in muscle will be compared between ALS patients and patients with other motor neuron diseases (SMA and SBMA)

Inclusion criteria :

- Patient with ALS, SMA, or SBMA

Exclusion criteria :

• Indication against biopsy (allergy to anesthetics local haemostasis disorders)
• Treatments that can affect muscle metabolism