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| Name | Class |
|---|---|
| Regionshospitalet Hammel Neurocenter | OTHER |
| Aarhus University Hospital | OTHER |
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The aim of this study is to determine whether noninvasive brain stimulation in form of active transcranial direct current stimulation (tDCS) combined with constraint induced movement therapy (CIMT) offers an additional benefit as compared with sham tDCS combined with CIMT in patients with stroke. Furthermore the purpose is to highlight changes in GABA activity more than 3 months after stroke and its importance for effect of tDCS and CIMT combined with tDCS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CIMT + active anodal tDCS | Experimental | Subjects in this group will be trained with constraint-induced movement therapy for the hand (10 consecutive sessions Monday- Friday) while concurrently receiving active anodal transcranial Direct Current Stimulation 1,5 mA for 30 min. |
|
| CIMT + sham tDCS | Sham Comparator | Subjects in this group will be trained with constraint-induced movement therapy for the hand (10 consecutive sessions Monday- Friday) while concurrently receiving sham transcranial Direct Current Stimulation |
|
| Healthy control subjects | No Intervention | 20 healthy age-matched control subjects will undergo MRI spectroscopy of the brain. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| active anodal transcranial Direct Current Stimulation (tDCS) | Device | Anodal transcranial Direct Current Stimulation 1.5 mA in 30 minutes with CIMT |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in Upper Limb function | The motor function assessment will be done with: Wolf Motor Function Test | Baseline and posttest (an average of 2 weeks from baseline) |
| Measure | Description | Time Frame |
|---|---|---|
| GABA (gamma-aminobutyric acid) activity | Assessment of GABA activity using MRI spectroscopy. Measurements will be compared between patients undergoing CIMT and healthy subjects. | Baseline |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Henning Andersen, Professor | Aarhus University Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Regionhospital Hammel Neurocenter, Research Unit | Hammel | 8450 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33175411 | Derived | Elsner B, Kugler J, Pohl M, Mehrholz J. Transcranial direct current stimulation (tDCS) for improving activities of daily living, and physical and cognitive functioning, in people after stroke. Cochrane Database Syst Rev. 2020 Nov 11;11(11):CD009645. doi: 10.1002/14651858.CD009645.pub4. | |
| 27899754 | Derived | Figlewski K, Blicher JU, Mortensen J, Severinsen KE, Nielsen JF, Andersen H. Transcranial Direct Current Stimulation Potentiates Improvements in Functional Ability in Patients With Chronic Stroke Receiving Constraint-Induced Movement Therapy. Stroke. 2017 Jan;48(1):229-232. doi: 10.1161/STROKEAHA.116.014988. Epub 2016 Nov 29. |
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|
| sham transcranial Direct Current Stimulation | Device | sham transcranial Direct Current Stimulation 30 min with CIMT |
|
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| Constraint Induced Movement Therapy (CIMT) | Behavioral | 2 weeks of CIMT |
|
|
| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| D000098483 | Constraint Induced Movement Therapy |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |
| D005081 | Exercise Therapy |
| D026741 | Physical Therapy Modalities |
| D012046 | Rehabilitation |
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