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To investigate whether reducing the volume (30 versus 10 ml) ropivacaine injected can reduce the number of subjects with impaired muscle strength following adductor canal block. We hypothesized that adductor canal block with 10 ml 0.1% ropivacaine preserves quadriceps strength compared with an adductor canal block with 30 ml.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 30 ml | Experimental | 30 ml ropivacaine 0.1%, single bolus |
|
| 10 ml | Experimental | 10 ml 0.1% ropivacaine, single bolus |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Adductor canal block with ropivacaine 0.1% | Procedure | US-guided adductor canal block |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of subjects with reduced quadriceps strength | The difference between the two volumes in number of subjects experiencing a reduction in quadriceps muscle strength by more than 25% from baseline in two consecutive assessments. | 0.5 to 6 hours post block |
| Measure | Description | Time Frame |
|---|---|---|
| Quadriceps strength in percentage of baseline | The difference between the two volumes in maximum voluntary isometric contraction (MVIC) of the quadriceps muscle, assessed as percentage of the baseline value. | 2, 3 and 4 hours post block |
| Quadriceps strength calculated as AUC |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Pia Jaeger, MD | Rigshospitalet, Denmark | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet | Copenhagen | 2100 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27799178 | Derived | Jaeger P, Grevstad U, Koscielniak-Nielsen ZJ, Sauter AR, Sorensen JK, Dahl JB. Does dexamethasone have a perineural mechanism of action? A paired, blinded, randomized, controlled study in healthy volunteers. Br J Anaesth. 2016 Nov;117(5):635-641. doi: 10.1093/bja/aew318. | |
| 26237001 | Derived | Jaeger P, Koscielniak-Nielsen ZJ, Hilsted KL, Fabritius ML, Dahl JB. Adductor Canal Block With 10 mL Versus 30 mL Local Anesthetics and Quadriceps Strength: A Paired, Blinded, Randomized Study in Healthy Volunteers. Reg Anesth Pain Med. 2015 Sep-Oct;40(5):553-8. doi: 10.1097/AAP.0000000000000298. |
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The difference between the two volumes in maximum voluntary isometric contraction (MVIC) of the quadriceps muscle calculated as "area under the curve" (AUC) |
| 30 minutes to 6 hours post block |
| Modified 30-second Chair Stand test | The difference between the pre block value and the post block value in the modified 30-second Chair Stand test performed on one leg, between the two volumes. | 2 and 4 hours post block |
| VAS pain scores during warmth stimulation | The difference between the two volumes in VAS pain score during warmth stimulation. | Mean value for the periode 30 minutes - 6 hours post block |