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We are evaluating the effect of methylene blue and visible light activation on the microbiome of the skin.
Antiseptics are routinely utilized to prevent infections of vascular catheters. We are evaluating the addition of methylene blue and light activation on skin to determine whether this inexpensive and non-toxic treatment can decrease skin pathogens and prevent blood stream infections of long-term vascular catheters. This is a pilot study of normal volunteers to determine the effect on the microbiome of the addition of methylene blue and light activation on antiseptic-treated skin.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Chloroprep and biopatch | No Intervention | Both arms are cleaned with chloroprep and a biopatch is placed on each arm. | |
| Methylene blue and light treatment | Experimental | Methylene blue and light treatment for 17 minutes are done twice over 1 week intervals. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Methylene blue and light treatment | Procedure | Methylene blue and light treatment for 17 minutes are done twice over 1 week intervals. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of the skin microbiome after methylene blue treatment | We compared the two arms of each subject --one arm treated with chloraprep and a biopatch [routine treatment of skin] to the routine treatment with the addition of methylene blue spray and light activation. The microbiome of both skin areas were assessed before and after the routine treatment and the treatment with the addition of methylene blue therapy; | 1 week |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jeanine Wiener-Kronish, MD | MGH | Principal Investigator |
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| ID | Term |
|---|---|
| D008751 | Methylene Blue |
| ID | Term |
|---|---|
| D010640 | Phenothiazines |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
| D006575 | Heterocyclic Compounds, 3-Ring |
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| D000072471 |
| Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |