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Potential biomarkers for obstructive sleep apnea (OSA), and full genomic screening will be evaluated and correlated to the degree of OSA and to effect of CPAP-treatment measured by polygraphy.
This project includes two parts:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Obstructive sleep apnea patients | Patients with obstructive sleep apnea that has not received CPAP treatment | ||
| Matched volunteers with non OSA | Matched volunteers without OSA. Matched in respect to age and BMI | ||
| Matched normal controls with normal BMI | Volunteers that are matched according to age but has a normal BMI |
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| Measure | Description | Time Frame |
|---|---|---|
| Biomarker | Biomarkers related to inflammation, hypoxia, oxidative stress, redox and the central nervous system will be measured | Comparison between 0, 3 and 12 month |
| Measure | Description | Time Frame |
|---|---|---|
| Genomics | Genomic screening by microarray | Comparison between 0, 3, 12 month |
| Apnea hypopnea index | Apnea hypopnea index at 0, 3 and 12 month after treatment with CPAP in the obstructive sleep apnea groups |
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OSA-patients with moderate and severe OSA (n=15+15)
Controls (AHI<5) Two groups of controls
Exclusion Criteria:
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OSA patients will be recruited from an outpatient sleep clinic
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| Name | Affiliation | Role |
|---|---|---|
| Malin Jonsson Fagerlund, MD, PhD | Karolinska University Hospital and Karolinska Institutet | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesiology, Surgical Sciences and Intensive Care Medicine, Karolinska University Hospital, Solna | Stockholm | SE-17176 | Sweden |
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| ID | Term |
|---|---|
| D020181 | Sleep Apnea, Obstructive |
| ID | Term |
|---|---|
| D012891 | Sleep Apnea Syndromes |
| D001049 | Apnea |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
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Whole blood, serum, plasma
| Comparision between 0, 3 and 12 month |
| Exhaled nitric oxide | Measurement of exhaled nitric oxide | Comparision at 0, 3 and 12 month |
| D020919 |
| Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |